α1,3-fucosyltransferase

Details α1,3-fucosyltransferase α1,3-fucosyltransferase

2007-01-23

2007-01-23

Prouty, Rebecca (Department: 1652)

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound containing saccharide radical

C435S193000, C435S072000, C435S074000, C536S023200

Reexamination Certificate

active

10120319

ABSTRACT:
A bacterial α1,3-fucosyltransferase gene and deduced amino acid sequence is provided. The gene is useful for preparing α1,3-fucosyltransferase polypeptide, and active fragment thereof, which can be used in the production of oligosaccharides such as Lewis X, Lewis Y, and siayl Lewis X, which are structurally similar to certain tumor-associated carbohy-drate antigens found in mammals. These product glycoconjugates also have research and diagnostic utility in the development of assays to detect mammalian tumors. In addition the polypeptide of the invention can be used to develop diagnostic and research assays to determine the presence ofH. pyloriin human specimens.

REFERENCES:
patent: 5324663 (1994-06-01), Lowe
GenBank Accession No. AE000554. Aug. 6, 1997.
GenBank Accession No. AE000578. Aug. 6, 1997.
J. Costa et al. “Stable Expression of the Golgi Form and Secretory Variants of Human Fucosyltransferase III From BHK-21 Cells.” J. Biol. Chem. 272(17): 11613-11621. Apr. 25, 1997.
D.A. Rasko et al. “Synthesis of Mono- and Di-fucosylated Type I Lewis Blood Group Antigens ByHelicobacter pylori”, Eur. J. Biochem. 267:6059-6066. (2000).
D.A. Rasko et al. “Cloning and Characterization of the Alpha-(1,3/4)-Fucosyltransferase ofHelicobacter pylori”, J. Biol. Chem. 275(7):4988-4994. (Feb. 2000).
B.J. Appelmelk et al. “Phase Variation inHelicobacter pyloriLipolysaccharide Due to Changes in the Lengths of Poly(C) Tracts in Alpha 3-Fucosyltransferase Genes”, Infect. Immun. 67(10): 5361-5366. (Oct. 1999).
Warren, J. R., and Marshall, B. J. (1983) Lancet, 1273-1275.
Graham, G. Y. (1991)J. Gastroenterol. Hepatol. 6, 105-113.
Parsonnet, J. et al., (1991)N. Engl. J. Med. 325, 1127-1131.
Forman, D. et al., (1993)Lancet 341, 1359-1362.
Nakamura, S. et al., (1997)Cancer 79, 3-11.
Wirth, H.-P. et al., (1996)Infect. Immun. 64, 4598-4605.
Feizi, T. (1985)Nature 314, 55-57.
Hakomori, S. (1989) Adv. Cancer Res. 52, 257-331.
Sherburne, R., and Taylor, D. E. (1995)Infect. Immun. 63, 4564-4568.
Weston, B. W., Smith, Kelly, R. J., and Lowe, J. B. (1992)J. Biol. Chem. 267, 24575-24584.
Gersten, K. M. et al., (1995)J. Biol. Chem. 270, 25047-25056.
Chan, N. W. C. et al., (1995)Glycobiology 5, 683-688.
Hitoshi, S., Kusunoki, S., Kanazawa, I., and Tsuji, S. (1996)J. Biol. Chem. 271, 16975-16981.
Goelz et al., (1990)Cell 63, 1349-1376.
Kukowska-Latallo, J. F., Larson, R. D., Nair, R. P., and Lowe, J. B. (1990)Genes&Dev. 4, 1288-1303.
Lowe et al., (1991)J. Biol. Chem. 266, 17467-17477.
Kumar, R., Potvin, B., Muller, W. A., and Stanley, P. (1991)J. Biol. Chem. 266, 21777-12783.
Weston, B. W., J. F., Nair, R. P., Larson, R. D., and Lowe, J. B. (1992)J. Biol. Chem. 267, 4152-41.
Koszdin, K. L., and Bowen, B. R. (1992)Biochem. Biophys. Res. Commun. 187, 152-157.
Sasaki et al., (1994)J. Biol. Chem. 269, 14730-14737.
Natsuka, S., Gersten, K. M., Zenita, K., Kannagi, R., and Lowe, J. B. (1994)J. Biol. Chem. 269, 16789-16794.
Lee et al., (1996)J. Biol. Chem. 271, 32960-32967.
Joziasse, D. H. (1992)Glycobiology 2, 217-277.
Paulson, S., and Colley, K. J. (1989)J. Biol. Chem. 264(30), 17615-17618.
Kelly, M. M., Phanhthourath, C., Brees, D. K., McCabe, C. F., and Cole, G. J. (1995)Dev. Brain Res.8: 31-47.
Peterson, W. I. (1991)N. Engl. J. Med. 324, 1043-1048.
Martin et al. (1997)J. Biol. Chem. 272(34) 21349-21356.
Ge et al. (1997)J. Biol. Chem. 272(34), 21357-21363.
Muramatsu, T. (1988)Biochimie 70, 1587-1596.
Tomb, J.F. et al., “Tfucosyltransferase ofHelicobactor pylori” EMBL database entry 025366, ascension 1998 (See abstract only).
Tomb, J.F. et al., “The complete genome sequence of the gastric pathogenHelicobacter pylori” NATURE, vol. 388:539-547 (Aug. 1997).

Affiliated with

Also associated with

Rating

α1,3-fucosyltransferase does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with α1,3-fucosyltransferase, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and α1,3-fucosyltransferase will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3744562