Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – Attached to or within viable or inviable whole...
Patent
1999-04-29
2000-12-12
Schwartzman, Robert A.
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
Attached to or within viable or inviable whole...
424 91, 424 9372, 435 6, 4353201, 435455, 536 231, A61K 5100, A01N 6300, C12Q 168, C12N 1563, C07H 2104
Patent
active
061594431
ABSTRACT:
A method of delivering an active agent to a target tissue, particularly neoplastic tissue, vascular anomaly or tumor tissue, in a vertebrate subject. The method includes the steps of exposing the target tissue to ionizing radiation; and administering a delivery vehicle to the vertebrate subject before, after, during, or combinations thereof, exposing the target tissue to the ionizing radiation. The delivery vehicle includes the active agent and delivers the agent to the target tissue. Exemplary delivery vehicles include platelets; leukocytes; proteins or peptides which bind activated platelets; antibodies which bind activated platelets; microspheres coated with proteins or peptides which bind activated platelets; liposomes conjugated to platelets, leukocytes, proteins or peptides which bind activated platelets, or antibodies which bind activated platelets; and combinations thereof.
REFERENCES:
patent: 4515165 (1985-05-01), Carroll
patent: 4670386 (1987-06-01), Sugaar
patent: 5292524 (1994-03-01), Male et al.
patent: 5328840 (1994-07-01), Coller
patent: 5334369 (1994-08-01), Halushka et al.
patent: 5382680 (1995-01-01), Abraham et al.
patent: 5516881 (1996-05-01), Lee et al.
patent: 5693627 (1997-12-01), Schieven
patent: 5759542 (1998-06-01), Gurewich
Weilchselbaum et al. Gene therapy targeted by radiation preferentially radiosensitizes tumor cells. Cancer Res. vol. 54:4266-4269, Aug. 1994.
Hirata et al. Artificial matastases and decresase of frbrinolysis in the nude mouse lung after hemithoracic irradiation. Clin Expl. Metastasis. Vol. 2:3311-319, Oct. 1984.
Hirata et al. Fate of intravenously injected human tumor cells in the lung of nude mice following whole body X-irradiation. Invasion Metastasis. Vol. 5:61-70, Jul. 1985.
Stratton et al. Imaging arterial thrombosis: Comparison of technetium-99m-labelled monoclonal antifibrin antibodies and indium-111-platelets. J. nucl. Med. vol. 35:1731-1737, Nov. 1994.
Sandals William
Schwartzman Robert A.
Vanderbilt University
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