X-ray-emitting interstitial implants

Details X-ray-emitting interstitial implants X-ray-emitting interstitial implants

1985-01-24

1987-10-27

Howell, Kyle L.

Surgery

Truss

Perineal

A61N 510

Patent

active

047022280

ABSTRACT:
Particles or "seeds" are manufactured for implantation into tumors within a human body for emitting X-rays to destroy or reduce the tumors. The seeds contain palladium which is substantially enriched in palladium-102 and which is activated by exposure to neutron flux so as to contain a minor, but significant, fraction of X-ray-emitting palladium-103. The palladium is distributed on or throughout a base material so as to reduce self-shielding by the palladium. The seeds include an X-ray-opaque marker to facilitate external visualization of the seeds after their implantation, the marker preferably being formed of a material, such as lead or rhodium, which does not activate to contain undesirable isotopes under the radiation conditions in which palladium-102 is activated to palladium-103. The base material-distributed palladium and the marker are encased in an elongated shell which is formed by welding a pair of end caps to a tubular member, the construction of the shell reducing the mass of material at the end of the seed, thereby providing a more isotropic angular distribution of X-rays.

REFERENCES:
patent: 3351049 (1965-04-01), Lawrence
patent: 4323055 (1982-04-01), Kubiatowicz
patent: 4510924 (1985-04-01), Gray
The Use of Iodine-125 for Interstitial Implants, U.S. Department of Health, Education, & Welfare, Publication (FDA), Hilaris et al., 76-8022, 1975.
Medical Physics Monograph No. 7, "Recent Advances in Brachytherapy Physics", D. R. Shearer, ed., pub. of Amer. Ass. of Physicists in Medicine.
Walter R. Scott, Radiology, 105, 454-455 (1972).

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