Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – X-ray contrast imaging agent
Patent
1994-05-17
1996-05-21
Hollinden, Gary E.
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
X-ray contrast imaging agent
424709, 514 54, A61K 4904
Patent
active
055187110
DESCRIPTION:
BRIEF SUMMARY
TECHNICAL FIELD
This invention relates to a barium sulfate contrast medium for use in X-ray examination by double contrast method of the large and small intestines, and also in computed tomography (X-ray CT) of the large intestine, practiced in the medical field.
BACKGROUND ART
In recent years, with the change in food life to European and American styles, large intestine cancer is remarkably increasing in Japan, too and the importance of large intestine examination has been rapidly recognized.
Nowadays, progress and propagation of diagnostic imaging by computed tomography (X-ray CT), ultra-sonography (US), magnetic resonance imaging (MRI), etc. are remarkable, and these diagnostic imagings have been also incorporated into the diagnostic region of tubular organs such as the large intestine. However, most of large intestine diseases stem from lesions occuring in mucosa, and for discovery of such lesions, as a matter of course, but also for grasping of detailed characteristics of the lesions, enema X-ray examination and endoscopy have been utilized as important means.
The enema X-ray examination methods known in the prior art may be broadly classified into the filling method, the double contrast method, the compression method, the mucosal relief method, etc., and according to the present standard of Ministry of Health and Welfare of Japan (reevaluation result), it is approved to use 200 to 2,000 ml of a 20 to 130 w/v % barium sulfate contrast medium.
Among these methods, since double contrast barium enema is optimum for imaging of lesions and diagnosis thereof, it holds the primary place in the current examinations.
The double contrast barium enema is a method, in which barium sulfate, a positive contrast medium, is coated as a thin layer on the inner walls of the large intestine, and air, a negative contrast medium, is simultaneously insufflated to inflate the large intestine, whereafter X-ray transmission is performed to image the state of the large intestine mucosa surface.
The double contrast barium enema includes the Fisher method (1923) in which an aqueous barium sulfate suspension with a concentration of about 40-50 w/v % is injected as a contrast medium after washing the intestine, the contrast medium is discharged out of the body and then air is insufflated before taking double contrast images; the Welin method (1953) in which after washing the intestine with quantities of water or enema as the primary treatment an aqueous barium sulfate suspension with a high concentration of about 100 w/v % is likewise charged into the intestine as a medium, the contrast medium is discharged out of the body and again a small amount of the contrast medium is injected with insufflation of air before taking double contrast images; and the modified Brown method (1963) in which the contents of the large intestine are removed without washing of the intestine by carrying out the preliminary treatment of application of strict diet control combined with administration of laxative, a barium sulfate contrast medium is charged into the intestine and double contrast images are taken without accompaniment of discharging of the barium sulfate contrast medium. Further, the modified Brown method has been improved so as to be well adapted for the Japanese and to give good double contrast images.
This modified Brown method is a method, in which after removal of the large intestine contents by injestion of low fat and low fiber meals (meals for contrast enema) combined with administration of laxative (saline laxative and contact evacuant), 200-300 ml of an aqueous barium sulfate suspension of a relatively higher concentration of about 60-80 w/v % is injected as a contrast medium into the intestine and, without being discharged, permitted to reach the deepest possible point of the large intestine by rolling the patient before insufflation of air for fluoroscopy or photographing. According to this method, it has become possible to visualize the state of the large intestine mucosa as fine network patterns.
Generally speaking, when a
REFERENCES:
patent: 3784681 (1974-01-01), Fischler
patent: 5160724 (1992-11-01), Tonariya et al.
patent: 5281408 (1994-01-01), Unger
Ishii Michiyuki
Noguchi Yukihiro
Shimizu Hiroaki
Togashi Mitsuo
Tojima Yoichi
Hollinden Gary E.
Ohta Seiyaku Kabushiki Kaisha
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