Wt1-interacting protein WTIP

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues

Reexamination Certificate

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C435S069100

Reexamination Certificate

active

10181804

ABSTRACT:
An isolated WT1 interacting protein having the amino acid sequence as set forth in SEQ ID NO: 2, or an isolated protein that has an amino acid sequence in which one or a plurality of amino acids have been substituted, deleted, inserted, and/or added is functionally equivalent to the protein having the amino acid sequence as set forth in SEQ ID NO: 2; and comprises the amino acid sequence from Glu at position449to Met at position541in SEQ ID NO: 2.

REFERENCES:
patent: WO 99/04265 (1999-01-01), None
Bedford et al. FBP WW domains and the Abl SH3 domain bind to a specific class of a proline-rich ligands. The EMBO J (1997) vol. 16 (9), pp. 2376-2383.
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Chan et al., “Forming Binding Proteins Bear WWP/WW Domains that Bind Proline-Rich Peptides and Functionally Resemble SH3 Domains,” EMBO J, vol. 15, No. 5, (1996), pp. 1045-1054.
Scanlan, “Antigens Recognized by Autologous Antibody in Patients with Renal-Cell Carcinoma,” Int. J. Cancer., vol. 83, (1999), pp. 456-464.
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“Homo sapienscDNA Clone Similar to WP:ZK1098.1 CE03847; Contains Element TAR1 Repetitive Element; mRNA Sequence,” National Cancer Institute, Database Accession No. AA902780, Apr. 9, 1998, Abstract, XP-002237464.
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Chew et al., “Renal Cancer Associated Antigen Precursor Sequence,” Database Swissprot ′Online, EBI, Hinxton, Cambridgeshire, U.K., Database Accession No. AAYO7O53, Jul. 2, 1999, Abstract, XP-002237467.
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