Wound treatment with keratinocytes on a solid support enclosed i

Details Wound treatment with keratinocytes on a solid support enclosed i Wound treatment with keratinocytes on a solid support enclosed i

1997-04-16

1999-10-26

Naff, David M.

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Animal or plant cell

424422, 435177, 435180, 435182, 435382, 435395, 435402, C12N 500, C12N 1104, A01N 6300, A61F 1300

Patent

active

059723327

ABSTRACT:
Devices and methods for enhancing the healing of wounds, especially chronic wounds (e.g., diabetic wounds), are provided involving the use of keratinocytes. Keratinocytes are grown on a transplantable solid support (e.g., collagen-coated beads), and the keratinocyte-coated solid support is placed in an enclosure. The enclosure, in turn, is placed in the wound for use as an interactive wound healing promoter. After the enclosure is placed in a wound, the wound may be covered with a dressing. The enclosure is degradable or non-degradable, and is constructed from a membrane or a porous polyester mesh material having pores that are either too small or large enough for keratinocytes to cross. A means may be attached to the enclosure to enable removing the enclosure from a wound.

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