Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1994-05-02
1997-02-18
LeGuyader, John L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 12, 514 21, 514871, 530382, 530351, 536 551, 424600, A61K 3836, A61K 3514, C08B 3708, C07K 1475
Patent
active
056042000
ABSTRACT:
A wound therapeutic mixture is formulated to work alone or in combination with human growth factors, and is useful for treatment of burns, open sores, incisions, and wounds. The mixture is comprised of a medical grade hyaluronic acid (hyaluronan) and tissue culture grade plasma-fibronectin in combination with calcium, phosphate, uric acid, urea, sodium, potassium, chloride, and magnesium, all elements found in amniotic fluid. The mixture creates a moist healing environment which simulates the fetal in utero wound healing matrix. The therapeutic mixture can be sterile or contain an FDA acceptable preservative system. The compositions may be in the form of a liquid, creme, ointment, gel, hydrogel, hydrocolloid or dressing.
REFERENCES:
patent: 3887703 (1975-06-01), Manoussos
patent: 4983580 (1991-01-01), Gibson
patent: 5036056 (1991-07-01), Kludas
Br. J. Obstet. Gynaecol. "Biochemical Composition of Amniotic Fluid and Extraembryonic Coelomic Fluid In The First Trimester of Pregnancy" Campbell et al. 99: 563-565 1992.
Clark "Cutaneous Wound Repair" In Physiology, Biochemistry & Molecular Biology of The Skin ed. Goldsmith pp. 576-601 1991.
Doillon et al. "Collagen-based Wound Dressing: Effects of Hyaluronic Acid & Fibronectin on Wound Healing" Biomaterials 7 3-8 1986.
Repesh et al. "Fibronectin Involvement in Granulation Tissue & Wound Healing In Rabbits" J Histochem Cytochem 30(4) 351-358 1982.
Mast et al. "Scarless Wound Healing In The Mammalian Fetus" Surg. Gyn. Ob. 174(5) 441-451. 1992.
Dawes Daniel L.
Degen Nancy J.
LeGuyader John L.
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