Wound-healing composition and method

Details Wound-healing composition and method Wound-healing composition and method

1994-05-20

1995-12-12

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Web, sheet or filament bases; compositions of bandages; or...

514559, A61K 970

Patent

active

054747821

ABSTRACT:
A wound-healing composition and method utilizing a compound of the Formula (I) ##STR1## or a pharmaceutically acceptable salt thereof.

REFERENCES:
patent: 3694557 (1972-09-01), Persinos
patent: 4120964 (1978-10-01), Hartenstein et al.
patent: 4183939 (1980-01-01), Gieske et al.
patent: 4597961 (1986-07-01), Etscorn
patent: 4782077 (1988-11-01), de la Parra
patent: 4844901 (1989-07-01), Keplinger et al.
patent: 5069904 (1991-12-01), Masterson
patent: 5156847 (1992-10-01), Lewis et al.
Lewis, W. H., et al., "Introduction to the Ethnobotanical Pharmacopeia of the . . . ", Medicinal and Poisonous Plants of the Tropics, The Netherlands (1987).
Vaisberg et al., "Taspine is the Cicatrizant Principle . . . ", Planta Medica 55 (1989).
Southan and Buckingham, Dictionary of Alkaloids, Chapman and Hall, London and New York, summary from pp. xxiv-xxv (1989).
Persinos Purdue et al., South American Plants II: Taspine Isolation and Anti-Inflammatory Activity, Journal of Pharmaceutical Sciences, vol. 68, No. 1, (Jan., 1979).
Webster's Third New International Dictionary, Ed. P. B. Gove, Merriam-Webster, Inc., Springfield, Massachusetts, pp. 108, 1707 & 2406, (1986).
Morrison and Boyd, Organic Chemistry, third edition, Allyn and Bacon, Inc. Boston, pp. 30-32 (1973).
Platanova, T. F., et al., "Study of Plant Alkaloids," Leontice ewersmannii, BGE, IV. Structure of the Alkaloid Taspine [1], pp. 2957-2961 (1956) (J. of General Chemistry U.S.S.R. 23: 921-926 (1953)).
Ross, Russell, "The Fibroblast and Wound Repair," Biol. Rev. 43, pp. 51-96 (1986).
Peacock, Jr., Wound Repair, Ch. 5, "Collagenolysis and The Biochemistry of Wound Healing," 3d Ed., pp. 102-140, W. B. Saunders, Philadelphia (1984).
Mustoe, Thomas., et al., "Accelerated Healing of Incisional Wounds in Rats Induced by Transforming Growth Factor-.beta.," Science 237: 1333-1335 (1987).
Porras-Reyes, Beatriz H., et al., "Enhancement of Wound Healing by the Alkaloid Taspine Defining Mechanism of Action," Proc. of the Soc. for Experimental Biology and Medicine 203: 18-25 (1993).

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