Wound dressing gel

Details Wound dressing gel Wound dressing gel

1999-08-26

2001-06-26

Page, Thurman K. (Department: 1615)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Web, sheet or filament bases; compositions of bandages; or...

C424S488000

Reexamination Certificate

active

06251424

ABSTRACT:

FIELD OF THE INVENTION
The present invention relates to a gel for use in dressing a wound and to a process for making a gel.
BACKGROUND
Hydrogels are known for the treatment of cuts, abrasions, bums and similar wounds and consist of a matrix of polymers with a water content of up to 96%. Known hydrogel dressings exhibit less than ideal adherence characteristics and need to be covered with a secondary dressing, and the fluid or bacterial permeability of the gel depends upon the nature of the dressing used. Hydrogels are absorbent and semi-transparent and prior to application they may be refrigerated, such that the cooling effect contributes to the relief of pain.
A hydrogel for use as a wound dressing is described in International Patent Publication No. WO 92/16245, consisting of a water insoluble, water swellable cross-linked cellulose derivative, water and a polyol component. The gel described in this publication is primarily directed to the removal of necrotic tissue, as it reduces the need for the use of a chemical debriding agent or surgical excision. Thus, the known gel provides a dressing which can combine the actions of debriding and cleansing, independent upon the extent of necrosis. Furthermore, the dressing is capable of breaking down necrotic tissue and retaining resultant debris.
However, a problem with known hydrogels, for application as wound dressings, is that their adherency tends to be less than ideal. Furthermore, there is a tendency for these known compounds to disintegrate in the wound and to cause maceration to the skin around the wound.
SUMMARY OF THE INVENTION
According to a first aspect of the present invention, there is provided a gel for use in dressing a wound, comprising a monovalent salt of a polygalacturonic acid derivative, another carboxy-polysaccharide and multivalent ions providing ionic cross-links between said monovalent salt and said other carboxy-polysaccharide.
Preferably, the salt of polygalacturonic acid derivative is sodium pectate. Preferably, the cart)oxy-polysaccharide is a monovalent salt of a carboxycellulose derivative, or a monovalent salt of an alginic acid derivative.
In a preferred embodiment, the salts include ions of sodium, potassium or ammonium.
Preferably, said carboxy-polysaccharide is sodium carboxymethylcellulose, or sodium alginic, acid.
According to a second aspect of the present invention, there is provided a process for making a gel, comprising steps of: preparing a solution including a water soluble salt of a polygalacturonic acid derivative and a water soluble salt of another carboxy-polysaccharide; preparing a cross-linking agent in the form of a solution; and blending said, solution of cross-linking agent with said water soluble salts to form a gel by effecting formation of ionic bonds between said salts.


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