Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Web – sheet or filament bases; compositions of bandages; or...
Patent
1996-03-05
1998-11-10
Page, Thurman K.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Web, sheet or filament bases; compositions of bandages; or...
424445, A61F 200, A61L 1500
Patent
active
058340076
DESCRIPTION:
BRIEF SUMMARY
TECHNICAL FIELD
The present invention relates to a wound-covering material which is suitably usable for a wound of an animal (inclusive of a human being), such as a burn and a bedsore. Further, the present invention relates to a wound-covering material which may be left stably standing on a wound for a long period of time; is capable of preventing exudation; and is capable of healing the wound without the necessity of exchange, even when the wound-covering material is kept under a condition such that it is closely attached or adhere to the surface of the wound. Further, the present invention relates to a wound-covering material having an analgesic function. Further, the present invention relates to a wound-covering material which is capable of healing a wound without the necessity of the implantation of skin, even when the wound to be healed is a wide-range full-thickness skin wound. Further, the present invention relates to a wound-covering material which is capable of promoting the healing of a wound while simultaneously preventing the infection of the wound. Furthermore, the present invention relates to a wound-covering composition which comprises, at least, water and the above-mentioned wound-covering material, and also to a wound-covering medium which includes a layer comprising the above-mentioned composition, and a low-water vapor-transmissive film disposed on the composition layer.
BACKGROUND ART
In various animals inclusive of human beings, it is considered that their skin has functions or roles of: (1) a barrier against stimuli (externally imparted to a living organism); and (2) the prevention of the escape of body fluid and protection of internal organs. When the tissue of the above-mentioned animal skin is damaged due to a wound such as a burn or a bedsore, it is necessary to temporarily cause a skin substitute to perform the above-mentioned functions of the normal skin.
Heretofore, there have been developed various wound-covering media which have a function of substituting for the skin functions until the wound is healed. Such wound-covering media may roughly be classified into the following types by the structures thereof: other, which are represented by woven fabric such as gauze, nonwoven fabric, or sponge, etc. polyurethane and silicone rubber, or from materials produced by (or derived from) living organisms such as chitin, collagen and fibrin; and also have a structure having a very poor porosity. material. the above-mentioned various kinds of structures.
From the viewpoint of substitution for skin functions, the above-mentioned various structures have both advantages and disadvantages, respectively. However, these structures do not effectively deal with a most serious problem: body fluid exuding from the surface of a wound, namely, exudate.
Heretofore, there have been common or accepted theories, such as a theory that how to discharge or absorb the exudate is important, from a viewpoint that the excess accumulation of the exudate capable of causing infection, etc., is seriously considered; or a theory that appropriate secretion and accumulation of the exudate are required in order to heal a wound, from a viewpoint that the excess dryness of the surface of the wound retards the healing thereof.
The above-mentioned type (1) of the wound-covering medium having a structure containing pores communicating with each other is based on the former theory that the efficient discharge of the exudate is seriously considered. Further, the above-mentioned type (3) of the wound-covering medium comprising fine particulate hydrogel is based on the theory that the exudate should be absorbed.
On the other hand, the above-mentioned type (2) of the wound-covering medium having a film structure having a poor porosity is based on the latter theory that the excess dryness of the wound surface should be prevented and a wetted condition thereof should be maintained so as to promote the healing of the wound.
However, in a case where the above-mentioned wound-covering medium having a good porosity is used, the d
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Ogita Biomaterial Laboratories Co. Ltd.
Page Thurman K.
Shelborne Kathryne E.
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