Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Reexamination Certificate
2006-02-28
2006-02-28
Romeo, David (Department: 1647)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Reexamination Certificate
active
07005499
ABSTRACT:
The present invention provides novel polypeptides, termed FCTRX polypeptides, as well as polynucleotides encoding FCTRX polypeptides and antibodies that immunospecifically bind to an FCTRX or a derivative, variant, mutant, or fragment of an FCTRX polypeptide, polynucleotide or antibody. The invention additionally provides methods in which the FCTRX polypeptide, polynucleotide and antibody are used in detection and treatment of a broad range of pathological states, as well as to other uses.
REFERENCES:
patent: 5871697 (1999-02-01), Rothberg et al.
patent: 6117989 (2000-09-01), Bandman et al.
patent: WO 97/34013 (1997-09-01), None
patent: WO 99/47669 (1999-09-01), None
patent: WO 00/55173 (2000-09-01), None
patent: WO 01/00828 (2001-01-01), None
Wang et al. mRNA differential display: application in the discovery of novel pharmacological targets. Trends Pharmacol Sci. Aug. 1996;17(8):276-9.
Schafer et al. The S100 family of EF-hand calcium-binding proteins: functions and pathology. Trends Biochem Sci. Apr. 1996;21(4)134-40.
Donato R. S100: a multigenic family of calcium-modulated proteins of the EF-hand type with intracellular and extracellular functional roles. Int J Biochem Cell Biol. Jul. 2001;33(7):637-68.
Bowie et al. Deciphering the message in protein sequences: tolerance to amino acid substitutions. Science, (Mar. 16, 1990) 247 (4948) 1306-10.
Ngo et al., in The Protein Folding Problem and Tertiary Structure Prediction, Merz and Le Grand (Eds), Aug. 1994, Springer Verlag, pp. 433 and 492-495.
Haynes et al. Proteome analysis: biological assay or data archive? Electrophoresis. Aug. 1998;19(11):1862-71.
Hancock WS. Do we have enough biomarkers? J Proteome Res. Jul.-Aug. 2004;3(4):685.
Allman et al. BCL-6 expression during B-cell activation. Blood. Jun. 15, 1996;87(12):5257-68.
Camby, I., F. Lefranc, et al., “Differential expression of S100 calcium-binding proteins characterizes distinct clinical entities in both WHO grade II and III astrocytic tumours”, Neuropathology and Applied Neurobiology, 26 (2000), pp 76-90.
Dale, I., M. K. Fagerhol, et al., “Purification and partial characterization of a highly immunogenic human leukocyte protein, the L1 antigen”, Euro J Biochem 134 (1983), pp 1-6.
De Ferrari, G. V. and N. C. Inestrosa, “Wnt signaling function in Alzheimer's disease”, Brain Research Reviews 33 (2000), pp 1-12.
Djukanovic, D., U. Hofmann, et al., “Comparison of S100 protein and MIA protein as serum marker for malignant melanoma”, Anticancer Research, 20 (2000), pp 2203-2208.
Donato, R., “Funcational roles of S100 proteins, calcium-binding proteins of the EF- hand type.” Biochimica et Biophysica Acta 1450 (1999), pp 191-231.
Huang, X., “A contig assembly program based on sensitive detection of fragment overlaps” Genomics 14 (1992), pp 18-25.
Kerlavage, A.R, Direct Submission. GenBank Accession No.: AA315020, 1997, pp 1-2.
Kligman, D. and D. C. Hilt, “The S100 protein family”, Trends Biochemistry Science 13 (1988), pp 437-443.
Kuhl, M., L. C. Sheldahl, et al., “The Wnt/Ca2+ pathway: a new vertebrate Wnt signaling pathway takes shape”, Trends Genet 16 (2000), pp 279-283.
Nacken, W., C. Sopalla, et al., “Biochemical characterization of the murine S100A9 (MRP14) protein suggests that is functionally equivalent to its human counterpart despite its low degree of sequence homology”, Eur J Biochem 267 (2000), pp 560-565.
Patapoutian, A. and L. F. Reichardt, “Roles of Wnt proteins in neural development and maintenance” Curr Opin Neurobiol 10 (2000), pp 392-399.
Peifer, M. and P. Polakis, “Wnt signaling in oncogenesis and embryogenesis—a look outside the nucleus”, Science 287(2000), pp 1606-1609.
Pietas, et al., “Human cDNA of a new member of the s100 protein family which is downregulated in lung carcinoma cells” Direct Submission. GenBank Accession No.: AY007220, 2000, pp. 1-2.
Sastry, M., R. R. Ketchem, et al., “The three-dimensional structure of Ca(2+)-bound calcyclin: implications for Ca(2+)-signal transduction by S100 proteins”, Structure 6 (1998), pp 223-231.
Sheng, J. G., R. E. Mrak, et al., “Overexpression of the neuritotrophic cytokine S100beta precedes the appearance of neuritic beta-amyloid plaques in APPV717F mice”, J Neurochem 74 (2000), pp 295-301.
Shimkets, R. A., D. G. Lowe, et al., “Gene expression analysis by transcript profiling coupled to a gene database query”, Nature Biotechnology 17 (1999), pp 798-803.
Smalley, M. J. and T. C. Dale, “Wnt signalling in mammalian development and cancer” Cancer Metastasis Rev 18(1999), pp 1-2. (Abstract Only).
Xu, K. and C. L. Geczy, “IFN-gamma and TNF regulate macrophage expression of the chemotactic S100 protein S100A8”, The Journal of Immunology, (2000), pp 4916-4923.
Adams, M.D. et al., “EST186826 HCC Cell Line (Metastasis to Liver in Mouse) II Homo Sapiens CDNA 5′ End mRNA Sequence”, Accession No.: AA315020, 1997, AND Adams, M.D. et al., “Initial Assessment of Human Gene Diversity and Expression Patterns Based Upon 83 Million Nucleotides of cDNA”,Nature, vol. 377, 1995, pp 3-174.
Marra, M. et al., “The WashU-HMMI Mouse EST Project”, Accession No.: W20659, 1996, nucleotides 1-1074.
Marra, M. et al., “The WashU-HHMI Mouse EST Project”, Accession No.: W34209, 1997, nucleotides 166-377.
Marra, M. et al., “The WashU-HMMI Mouse EST Project”, Accession No.: AA638675, 1997, nucleotides 175-386.
Marra, M. et al., “The WashU-HMMI Mouse EST Project”, Accession No.: 726094, 1998, nucleotides 1-483.
Brown, A., “Commentary: Wnt signaling in breat cancer: have we come full circle?,”Breast Cancer Research, vol. 3, No. 6, pp. 351-355 (2001).
Nusse, R. et al., “Wnt Genes,” Cell, vol. 69, pp. 1073-1087 (Jun. 26, 1992).
Tsukamoto, A. et al., “Expression of the int-1 Gene in Transgenic Mice Is Associated with Mammary Gland Hyperplasia and Adenocarcinomas in Male and Female Mice,”Cell, vol. 5, pp. 619-625 (Nov. 18, 1988).
Wong, G. et al., “Differential Transformation of Mammary Epithelial Cells by Wnt Genes,”Molecular And Cellular Biology, vol. 14, No. 9, pp. 6278-6286 (Sep. 1994).
Lewin David A.
Pennica Diane
Rastelli Luca
Taillon Bruce
Curagen Corporation
Genentech Inc.
Merchant & Gould P.C.
Romeo David
LandOfFree
Wnt-regulated cytokine-like polypeptide and nucleic acids... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Wnt-regulated cytokine-like polypeptide and nucleic acids..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Wnt-regulated cytokine-like polypeptide and nucleic acids... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3659168