Wnt-3 polynucleotides

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...

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4353201, 435325, 435440, 536 231, 536235, C12N 1511, C12N 500, C12N 1500, C07N 2104

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active

060430532

ABSTRACT:
Wnt-3 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing Wnt-3 polypeptides and polynucleotides in therapy, and diagnostic assays for such.

REFERENCES:
Roelink et al. "Wnt-3, a gene activated by proviral insertion in mouse mammary tumors, is homologous to int-1/Wnt-1 and is normally expressed in mouse embryos and adult brain", Proc. Natl Acad. Sci, vol. 87, pp. 4519-4523 (1990).
Roelink et al. "Molecular Cloning and Chromosomal Localization to 17q21 of the Human WNT3 Gene", Genomics, vol. 17, pp. 790-792 (1993).
GenBank Accession No. M32502.
HGS EST HEBFU15.
PIR Accession #A35503.
PIR Accession #A48828.
PIR Accession A47536.
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Dale. Signal transduction by the Wnt family of ligands. Biochem. J. 329: 209-223 especially pp. 7 and 40, 1998.
Anderson. Human gene therapy. Nature 392: 25-30, especially p. 25, Apr., 1998.
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Roelink et al. Wnt-3, a gene activated by proviral insertion in mouse mammary tumors, is homologous to int-1/Wnt-1 and is normally expressed in mouse embryos and adult brain. Proc. Nat. Aca. Sci. USA 87: 4519-4523, Jun., 1990.
Roelink et al. GeneBank Accesssion No. M32502, Dec., 1996.
Fukushima et al. Nucleotide sequence of cloned cDNA for human pancreatic kallikrein. Biochemistry 24: 8037-8043, especially abstract, Fig. 1, and Fig. 2, 1985.

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