Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2008-04-29
2008-04-29
Nashed, Nashaat T. (Department: 1656)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C435S069100, C435S325000, C435S253300, C514S04400A
Reexamination Certificate
active
07365175
ABSTRACT:
The present invention provides a method of treatment to improve wound healing and to minimize/prevent abnormal scarring caused by tissue contraction and fibrosis formation by providing a specific gene, Wit 3.0 alpha and beta sequences that is differentially expressed in wounded oral mucosa cells, relative to their decreased expression in non-wounded oral mucosa cells. One aspect of the invention is a method to treat soft tissue wound using anti-sense nucleic acid technologies. Another aspect of the present invention is a method to treat soft tissue wound using sense nucleic acid technologies. These methods can employ a complimentary nucleic acid sequence that is greater than 85% identity to Wit 3.0 alpha and/or beta sequences or greater than 90% identity to the deduced amino acids thereof.
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Attachment 2: the sequence of Accession No. AK004662.
Attachment 3: the sequence of Accession No. AK050102.
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Nishimura Ichiro
Sukotjo Cortino
Liu Samuel Wei
Nashed Nashaat T.
The Regents of the University of California
Townsend and Townsend / and Crew LLP
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