Wire guides having novel outer surface areas and reservoirs...

Surgery – Diagnostic testing – Flexible catheter guide

Reexamination Certificate

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C604S500000, C604S506000

Reexamination Certificate

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07637873

ABSTRACT:
Wire guides and methods of using an elongate wire guide with a first end portion and a flexible second end portion having an increased surface area is provided. The second end portion comprises a nominal outer circumference disposed about a longitudinal axis and having a first outer surface including the nominal outer circumference and defining a first surface area. Protuberances, indentations, peaks, and/or valleys are disposed substantially circumferentially about the nominal outer circumference and defining an effective perimeter greater than the nominal outer circumference and having a second outer surface defining a second surface area greater than the first surface area. Hydrophilic materials and therapeutic agents may be disposed partially on the second end portion and a coating, and a membrane may be disposed about second end portion and coating to form reservoirs or lumens for delivering hydrophilic materials and delivering therapeutic agents.

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Written Opinion, dated Mar. 8, 2007, for International Application No. PCT/US2006/009171.
Search Report and Written Opinion, dated Jul. 11, 2006, for International Application No. PCT/US2006/009171.

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