Wire for medical use coated with polyether sulphone and a copoly

Surgery – Diagnostic testing – Flexible catheter guide

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

604280, A61M 2509

Patent

active

060865474

DESCRIPTION:

BRIEF SUMMARY
The present invention relates to a wire for medical use comprising a substrate provided with a first layer and a polymer layer applied thereto. The present invention furthermore relates to a method for producing such a wire.
A wire of this type for medical use is known from European Patent Application 0 389 632. Said European patent application relates to a medical instrument having good sliding properties, such as an instrument used for catheterisation, whereby the surface of a base material, which is coated with a component A, is coated with component B. A polymer having at least one reactive functional group selected from the group consisting of alkali metal alcoholate groups, amino group, alkali metal amide groups, carboxylic acid group, sulphonic acid group, magnesium halogenide groups and fluorinated boron complex groups is used as component A. A hydrophilic polymer having a reactive heterocyclic group being reactive with the reactive functional groups in the component A is used as component B. Several plastics, metallic wires, stainless steel, ceramics and wood are named as the base material. Component A is preferably applied to the base material by dipping or spincoating, using a solution in which a specified amount of component A is dissolved, followed by drying. The proportion of component A in the solution may range from 0.01-50% by weight. Alcohols, halogenated hydrocarbons, ketones, amides and linear or cyclic hydrocarbons are named as solvents. The surface of the base material, which is coated with component A, is then coated with component B dissolved in a solvent, using the same method as used for applying component A. After component B has been applied a reaction is effected between component A and component B by using a heat treatment.
From European Patent Application 0 166 998 a medical instrument is known which comprises a substrate containing a reactive functional group, at least on its surface, which group is covalently bound to a water-soluble polymer or a derivate thereof, as a result of which a lubricating effect is obtained by contacting the treated surface with water. Examples of the reactive functional groups include a diazonium group, azide group, isocyanate group, acid chloride group, acid anhydride group, imino carbonate group, amino group, carboxyl group, epoxy group, hydroxyl group and aldehyde group. The water-soluble polymer is selected from the group consisting of a cellulosic polymer, a maleic acid anhydride polymer, a polyacrylamide and a water-soluble nylon or a derivative thereof.
Further research has shown that a guide wire for medical use, in particular for diagnostic purposes such as catheterisation, must have a very smooth outer surface. During the diagnostic examination the guide wire is introduced into for example the patient's vascular system, and the smooth outer surface of the guide wire ensures that the tissue, in particular the walls of the blood vessels, is not damaged. Since the outer surface is very smooth, the amount of friction is quite low, so that no tissue is damaged. In addition to that the smooth outer surface must comprise a hydrophilic polymer, which makes the guide wire smooth after being immersed in an aqueous solution or a saline solution prior to being introduced into the human body.
The wire according to the invention as referred to in the introduction is characterized in that said first layer is polyether sulphone and that said polymer layer is a hydrophilic copolymer built up of an N-vinyl lactam compound and an alkyl (meth)acrylate compound.
The term "N-vinyl lactam compound" used herein is understood to include N-vinyl pyrrolidone, N-vinyl butyrolactam, N-vinyl caprolactam and the like. Examples of alkyl(meth)acrylate compounds are methyl methacrylate, ethyl methacrylate, propyl methacrylate, n-butyl methacrylate, isobutyl methacrylate, hexyl methacrylate, methyl acrylate, ethyl acrylate, propyl acrylate and hexyl acrylate. The substrate according to the invention is preferably a metal wire.
The hydrophilic copolymer as used on the wir

REFERENCES:
patent: 4534363 (1985-08-01), Gold
patent: 5001825 (1991-03-01), Halpern
patent: 5333620 (1994-08-01), Maitafis et al.
patent: 5372144 (1994-12-01), Morher et al.
patent: 5453467 (1995-09-01), Bamford et al.
patent: 5749837 (1998-05-01), Palermo et al.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Wire for medical use coated with polyether sulphone and a copoly does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Wire for medical use coated with polyether sulphone and a copoly, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Wire for medical use coated with polyether sulphone and a copoly will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-537021

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.