Wilson's disease gene

Chemistry: molecular biology and microbiology – Vector – per se

Patent

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Details

4351723, 435183, 435196, 536 235, 536 2431, 935 23, 935 24, 935 29, 935 9, C07H 2100, C12N 900, C12N 1512, C12N 1563

Patent

active

055784933

ABSTRACT:
This invention provides an isolated, vertebrate nucleic acid molecule encoding the normal protein that prevents development of Wilson's disease. This invention also provides a nucleic acid molecule comprising a nucleic acid molecule of at least 15 nucleotides capable of specifically hybridizing with a sequence included within the sequence of the above-described nucleic acid molecule. Finally, this invention provides various uses of the isolated Wilson's disease gene.

REFERENCES:
Kooy et al. 1993 Human Genetics 91:504-506.
Vulpe et al. 1993. Nature Genetics 3:7-13.
Chelly et al. 1993. Nature Genetics 3:14-19.
Mercer et al. 1993. Nature Genetics 3:20-25.
Chelly et al. 1993. Nature Genetis 5:317-318.
Bull et al. 1993 Nature Genetics 5:327-337.
Petrukhin et al. 1993. Nature Genetics 5:338-343.
Tanzi et al. 1993. Nature Genetics 5:344-350.
Yamaguchi et al. 1993. Biochem. Biophys. Res. Comm. 197(1):271-277.
Watson, 1993. Tibtech 11:114-117.

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