Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1993-01-08
1998-08-25
Sidberry, Hazel F.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
4241841, 4241851, 4242421, 4242531, 4242541, 530350, 435 691, 435 693, 435 697, 435 711, A61K 3902, A61K 3910, A61K 2102
Patent
active
057981035
ABSTRACT:
The invention relates to acellular vaccines being effective against whooping cough and is based on a functional component of the fimbriae of Bordetella pertussis i.e. the actual adhesin molecule being a "minor" component in the fimbriae. The vaccines according to the invention have the advantage that both they may induce an effective immune respons against all B. pertussis strains and--most likely--also against Bordetella paratertussis being the second important causative agent of whooping cough. Further, the vaccines may also be used for veterinary applications, to protect against Bordetella bronchiseptica infections.
REFERENCES:
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Weiss et al Ann. Review Microbiol 40: 661-86, 1980 Virulence Factors of Bordetella Pertussis.
Kimura et al Infect. & Immunity 58:7-16, 1990 Bordetella pertussis Filamentons Hemagglutinin: Evaluation as Protective Antigen & Colonization Factor in Mouse Respiratory Infection Model.
Mooi et al Microbial Pathogenesis 12:127-135, 1992.
Robinson et al Vaccine 3:11-22, 1985.
Novotry et al The Journal of Infect. Diseases 164:114-22, 1991.
"Microbial Pathogenesis", Characterization of Fimbrial Subunits from Bordetella Species, vol. 2, 1987, pp. 473-484 by Frits R. Mooi et al.
"Tokai Journal of Experimental Clinical Medicine", Bordetella Pertussis Pilin and Pilin-Like Genes, vol. 13, suppl. 1988, pp. 235-237 by F. de Ferra et al.
De Staat der Nerderlanden Vertegenwoordigd Door de Minister Van
Sidberry Hazel F.
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