Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Reexamination Certificate
2006-04-25
2006-04-25
Park, Hankyel T. (Department: 1648)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
C435S006120
Reexamination Certificate
active
07033781
ABSTRACT:
An invention comprising cellular transformation, directed evolution, and screening methods for creating novel transgenic organisms having desirable properties. Thus in one aspect, this invention relates to a method of generating a transgenic organism, such as a microbe or a plant, having a plurality of traits that are differentially activatable. Also, a method of retooling genes and gene pathways by the introduction of regulatory sequences, such as promoters, that are operable in an intended host, thus conferring operability to a novel gene pathway when it is introduced into an intended host. For example a novel man-made gene pathway, generated based on microbially-derived progenitor templates, that is operable in a plant cell. Furthermore, a method of generating novel host organisms having increased expression of desirable traits, recombinant genes, and gene products.
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Hutchison et al., “Global Transposon Mutagenesis and a Minimal Mycoplasma Genome,” Science, vol. 286, No. 5447, Dec. 10, 1999, pp 2165-2169.
“Defined Oligonucleotide Tag Pools and PCR Screening in Signature-Tagged Mutagenesis of Essential Genes From Bacteria,” Biotechniques, Eaton Publishing, vol. 26, No. 3, Mar. 1999, pp 473-474, 476, 478-480.
Hensel et al., “Simultaneous Identification of Bacterial Virulence Genes by Negative Selection,” Science, vol. 269, Jul. 21, 1995, pp 400-403.
Diversa Corporation
Hale and Dorr LLP
Love Jane M.
Park Hankyel T.
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