Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Conjugate or complex
Reexamination Certificate
1997-12-08
2001-03-06
Tate, Christopher (Department: 1651)
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Conjugate or complex
C424S401000, C424S062000
Reexamination Certificate
active
06197304
ABSTRACT:
FIELD OF THE INVENTION
The present invention relates to cosmetic products having whitening effect, which contains solvent-fractionated extracts of
Ramulus mori
extracts that is extracted from young twig of plants belonged to
Morus
Genus.
PRIOR ARTS
In general, there are various reasons for the darkening of skin color. And the main reason is ultraviolet radiation. When skin is exposed to ultraviolet ray, melanin is synthesized in melanocytes, which is a kind of skin cells, and released to darken skin color. In the process of melanin synthesis in melanocytes, tyrosinase reacts on tyrosine, which is a substrate for tyrosinase, in the cell to yield Dopaquinone and it goes through spontaneous reaction and enzyme reaction to synthesize a copolymeric black pigment, melanin. Thus, to prevent darkening of skin color, it is most simple and general to inhibit a step of the process of generating melanin, to reduce the production of melanin.
For this reason, ascorbic acid, kojic acid, arbutin, hydroquinone or plant extracts like
Cortex mori
extracts have been conventionally used as whitening agents up to the present.
Among these, kojic acid forms a chelate with a copper ion at the active site of tyrosinase to inhibit the enzyme activity. Though it has high activity, it is not appropriate to be used in cosmetics because of its stability problem in the process of mixing in the cosmetic products.
Ascorbic acid cannot be properly used as a whitening agent because it has relatively low activity of inhibiting tyrosinase and low stability of the molecule itself.
Hydroquinone irritates the skin strongly, so that it is not used as a cosmetic material in these days because of its safety problem.
Most of plant extracts can reveal substantial inhibition effect on tyrosinase activity, only if they are used at a high concentration. When they are used at a low concentration, the inhibiting activity hardly occurs.
SUMMARY OF THE INVENTION
The present inventors have paid attention to these circumstances and performed intensive studies for finding a more excellent whitening agent which does not involve the problems of conventional whitening agents. As a result of searching for effective material having whitening activity among the natural plants of which the safety has been already proved as they have been used in herb remedies or folk remedies for a long time, the inventors found that the extracts of
Ramulus mori
, young twig of plants belonged to
Morus
Genus, showed excellent inhibition activity on tyrosinase. The result was filed as an invention with the Korea Industrial Property Office.
The object of the present invention is to provide whitening cosmetics containing solvent-fractionated extracts of
Ramulus mori
extracts.
In order to find a whitening agent having stronger effect of inhibiting tyrosinase, from
Ramulus mori
extracts, the inventors attempted solvent-fractionating of the extracts by the use of various organic solvents. As a result, they found that the solvent-fractionated extracts of
Ramulus mori
extracts has stronger effect of inhibiting tyrosinase activity than
Ramulus mori
extracts did, so that strongly inhibit the synthesis of melanin in melanocytes, to complete the invention.
REFERENCES:
patent: 4137231 (1979-01-01), Murai et al.
patent: 5773014 (1998-06-01), Perrier et al.
patent: 5872254 (1999-02-01), Kim et al.
patent: 8150538 (1983-09-01), None
patent: 9227353 (1997-09-01), None
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Cosmetics & Toiletries magazine; vol. 111, Oct. 1996; pp. 65-77; “Skin Lighteners”.
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Kim Jeong-Ha
Lee Kang-Tae
Coreana Cosemetics Co., Ltd.
Nields & Lemack
Tate Christopher
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