West Nile viruses with mutations in the 3′ terminal...

Details West Nile viruses with mutations in the 3′ terminal... West Nile viruses with mutations in the 3′ terminal...

2005-06-14

2010-12-14

Mosher, Mary E (Department: 1648)

Chemistry: molecular biology and microbiology

Virus or bacteriophage, except for viral vector or...

C435S236000, C435S005000, C435S471000, C424S199100, C424S218100

Reexamination Certificate

active

07851194

ABSTRACT:
The invention provides West Nile (WN) viruses and chimeric WN viruses having one or more mutations in the 3′ terminal stem loop secondary structure (3′SL) that results in decreased neurovirulence, methods of making such WN viruses, and methods for using these WN viruses to prevent or treat WN virus infection.

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