Chemistry: molecular biology and microbiology – Apparatus – Including measuring or testing
Reexamination Certificate
2006-04-04
2006-04-04
Redding, David (Department: 1744)
Chemistry: molecular biology and microbiology
Apparatus
Including measuring or testing
C435S288500, C435S288600, C435S288700
Reexamination Certificate
active
07022516
ABSTRACT:
The present invention aims at providing a well unit to be used in fabricating an apparatus whereby movements of cells based on their own actions can be accurately and easily detected, in detecting the chemotaxis of cells due to a chemotactic factor or the inhibition of the chemotaxis of cells by an inhibitor.Accordingly, the present invention provides a well unit to be used in an apparatus for detecting chemotaxis of cells and separating cells characterized in that a plural number of wells, in which a liquid sample can be held in a resting state, are connected to each other via a channel, the channel is provided with a bank, and, in the upper part of the bank, barriers constituting one or more grooves having a width and/or a depth fit for the diameter or deformability of cells are provided or a plane is provided so as to give a gap having a depth fit for the diameter or deformability of cells between the plane and the glass substrate.
REFERENCES:
patent: 3888770 (1975-06-01), Avital et al.
patent: 3929583 (1975-12-01), Sharpe et al.
patent: 4317726 (1982-03-01), Shepel
patent: 4493815 (1985-01-01), Fernwood et al.
patent: 4514495 (1985-04-01), Schalkowsky et al.
patent: 4714674 (1987-12-01), Palladino
patent: 4729949 (1988-03-01), Weinreb et al.
patent: 4833382 (1989-05-01), Gibbs
patent: 4895805 (1990-01-01), Sato et al.
patent: 4912057 (1990-03-01), Guirguis et al.
patent: 5023173 (1991-06-01), Horowitz et al.
patent: 5284753 (1994-02-01), Goodwin, Jr.
patent: 5302515 (1994-04-01), Goodwin, Jr.
patent: 5744366 (1998-04-01), Kricka et al.
patent: 6395505 (2002-05-01), Goodwin, Jr.
patent: 2002/0009796 (2002-01-01), Goodwin, Jr.
patent: 2002/0086280 (2002-07-01), Lynes et al.
patent: 2003/0003570 (2003-01-01), Kanegasaki et al.
patent: 0 368 241 (1990-05-01), None
patent: 368241 (1990-05-01), None
patent: 3-257366 (1991-11-01), None
patent: 257366/1991 (1991-11-01), None
patent: 8-23967 (1996-01-01), None
patent: 23967/1996 (1996-01-01), None
patent: 11-165062 (1999-06-01), None
patent: 165062/1999 (1999-06-01), None
patent: 94/16098 (1994-07-01), None
patent: WO 94/16098 (1994-07-01), None
patent: 96/03206 (1996-02-01), None
patent: WO 96/03206 (1996-08-01), None
patent: WO 00/07007 (2000-10-01), None
patent: WO 01/32827 (2001-10-01), None
Falk, W. et al., Journal of Immunological Methods, 33:239-247(1980).
Gatewood, B. et al., Journal of Immunology, 147:243-246(1991).
Falk, W. et al., Infection and Immunity; 36:450-454(1982).
Harvath, L. et al., Infection and Immunity, 36:443-449(1982).
Richards, K. K. et al., Immunological Communications, 13:49-62(1984).
Nelson, R. D. et al., J. Immunol., 115:1650-1656(1975).
Repo, H., Scand. J. Immunol., 6:203-209(1977).
Junger, W. G. et al., J. Immun. Methods, 160:73-79(1993).
Kikuchi, Y. et al., Microvascular Research, 44:226-240(1992).
Kikuchi, Y. et al., SPIE 2978:165-171(1997).
Kikuchi, Y. et al., Journal of the Japan Society for Precision Engineering, 62:1553-1556(1996).
Cutler, J. et al., Proc. Soc. Exp. Biol. Med., 147: 471-474 (1974).
John, T. J. et al., Life Science, 18:177-182 (1976).
Harvath, L. et al., Journal of Immunological Methods, 37:39-45 (1980).
Zigmond, S. H. et al., Annual Review of Medicine, 37:149-155 (1986).
Boyden, Department of Experimental Pathology, John Curtin School of Medical Research, Australian National University, Canberra, pp. 453-466 (1961).
Francis et al., Proc. Natl. Acad. Sci. USA, vol. 94, pp. 12258-12262 (Nov. 1997).
Kikuchi, Microvascular Research, vol. 50, pp. 288-300 (1995).
Kobayashi et al., J. Biochem, vol. 117, pp. 758-765 (1995).
Lehninger, Biochemistry, Second Edition,The Molecular Basis of Cell Structure and Function, pp. 173-181 (1978).
Mazumder et al., Journal of Crystal Growth, vol. 224, pp. 165-174 (2001).
Junger, W.G. et al., Journal of Immunological Methods, Mar. 15, 1993, vol. 160, No. 1, pp. 73 to 79.
Kikuchi, Y. et al., Chemical Engineering, 62:136-138(1998).
Kikuchy, Y. et al., Biophysics 37:254-258(1997).
Zigmond, S. H., J. Cell Biology 75:606-616(1977).
Allen, W. E. et al., J. Cell Biology, 141:1147-1157(1998).
Zicha, D. et al., J. Cell Science 99:769-775(1991).
Neuro Probe, Inc. “Neuro Probe Zigmond Chamber”.
Weber Scientific, Inc. “Dunn Chemotaxis Chamber”.
Kanegasaki Shiro
Kikuchi Hiroko
Kikuchi Yuji
Birch & Stewart Kolasch & Birch, LLP
Effector Cell Institute
Redding David
LandOfFree
Well unit for detecting cell chemotaxis and separating... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Well unit for detecting cell chemotaxis and separating..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Well unit for detecting cell chemotaxis and separating... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3594454