Drug – bio-affecting and body treating compositions – Baits – attractants – or lures
Reexamination Certificate
1999-08-30
2001-08-07
Tate, Christopher R. (Department: 1651)
Drug, bio-affecting and body treating compositions
Baits, attractants, or lures
C424S085500, C424S573000, C424S574000, C424S578000, C514S909000
Reexamination Certificate
active
06270756
ABSTRACT:
BACKGROUND OF THE INVENTION
Body weight and obesity are like the weather: Everyone talks about it, but no one seems able to do much about it. In recent years researchers have learned a great deal about the cause and ramifications of obesity. Metabolism-the way we absorb, utilize, break down and eliminate the waste from food stuffs-is only a part of the difference between individuals. In order to understand these differences, the playing field must be analyzed, not a macro-cellular level, but rather at a micro-cellular level.
At the micro-cellular level, uncoupling proteins (UCPs) have been found to exist and they dissociate the reactions that break down food from those that produce the body's chemical energy. These UCPs let hydrogen ions pass through the cellular inner mitochondrial membrane, thereby abolishing the hydrogen ion gradient needed to drive ATP synthesis. If the UCPs activity could be increased by 1-2% then there would be an increase fat oxidation and thermogenesis. This would translate into a boost in resting metabolic rates and subsequent weight loss for millions of individuals. A technique to increase the action of the body's own uncoupling proteins would be very desirable, and could add years of life for certain individuals.
SUMMARY OF THE INVENTION
In one embodiment of the invention, there is provided a method for promoting weight loss in humans. The method is carried out by administering effective amount of a substance which actuates the production and release of ZAG proteins from lymphocytes, but preferably beneath an amount which causes side effects.
In another embodiment of the invention, there is provided a composition of matter highly suitable for use in the above method. The composition comprises a dilute mixture of alfa interferon and gamma interferon in an aqueous medium. The concentration and daily dosage of the interferons is generally well beneath concentrations and dosages employed for antibiotic purposes.
In still another embodiment of the invention, there is provided a method for causing weight loss in humans which is more effective than fasting. The method is carried out by administering an effective amount of a weight-loss composition comprising both alfa interferon and gamma interferon on a daily basis for a period of time in the range of 3 days to 30 days. At least during the initial part of the period, weight loss for many individuals occurs at a greater rate than would be caused by fasting.
In still another embodiment of the invention, there is provided a method for a human to self-induce weight loss. The method is carried out by self-administering an effective amount of a weight-loss composition in a manner and amount as described above.
REFERENCES:
Flores et al., J Clin Invest., vol. 83: 1614-1622. Infusion of tumor necrosis factor/cachectin promotes muscle catabolism in the rat: a synergistic effect with interleukin 1, 1989.*
Byrsk et al., Anticancer Research, vol. 17: 3387-3392. Modulation by interferon-gamma of zinc-alpha2-glycoprotein gene expression in human epithelial cell lines, 1997.*
Todorov et al., Cancer Research, vol. 58: 2353-2358. Purification and characterization of a tumor lipid-mobilizing factor, Jun. 1, 1998.
Casperson John R
Flood Michele
RX/IBR Corporation
Tate Christopher R.
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