WD-40-derived peptides and uses thereof

Details WD-40-derived peptides and uses thereof WD-40-derived peptides and uses thereof

1994-02-01

1996-05-21

Wax, Robert A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530328, 530329, 435194, A61K 3808, C07K 706

Patent

active

055190030

ABSTRACT:
The present invention relates to a polypeptide composition effective to alter the activity of a first protein that interacts with a second protein, where the second protein contains at least one WD-40 region. The polypeptides of the present invention typically have between 4 and 50 amino acids whose sequence is the same as a sequence of the same length in the WD-40 region of the second protein. The invention further includes a method of altering the activity of the above described first protein. In one embodiment of the invention the polypeptide composition is effective to alter the activity of a protein kinase C, where the protein kinase C interacts with a second protein, and the second protein contains at least one WD-40 region (e.g., RACK1).

REFERENCES:
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Dynlacht, B. D., et al., "The dTAF.sub.II 80 subunit of Drosophila TFIID contains .beta.-transducin repeats," Nature 363: 176-179 (1993).
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Guillemot, F., et al., "Physical linkage of a guanine nucleotide-binding protein-related gene to the chicken major histocompatibility complex," Proc. Natl. Acad. Sci. USA 86: 4594-4598 (1989).
Keleher, C. A., et al., "Ssn6-Tup1 Is a General Repressor of Transcription in Yeast," Cell 68: 709-719 (1992).
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Peitsch, M. C., et al., "Sequence similarity of phospholipase A2 activating protein and the G protein .beta.-subunits: a new concept of effector protein activation in signal transduction?," TIBS 18(8): 292-293 (1993).
Smith, B. L., and D. Mochly-Rosen, "Inhibition of Protein Kinase C Function by Injection of Intracellular Receptors for the Enzyme," Biochem. Biophys. Res. Comm. 188(3): 1235-1240 (1992).
Takagaki, Y., and J. L. Manley, "A Human Polyadenylation Factor Is a G Protein .beta.-Subunit Homologue," J. Biol. Chem. 267(33): 23471-23474 (1992).
van der Voorn, L., and H. L. Ploegh, "The WD-40 repeat," FEBS Lett. 307(2): 131-134 (1992).
Williams, F. E., and R. J. Trumbly, "Characterization of TUP1, a Mediator of Glucose Repression in Saccharomyces cerevisiae," Mol. Cell. Biol. 10(12): 6500-6511 (1990).
Williams, F. E., et al., "The CYC8 and TUP1 Proteins Involved in Glucose Repression in Saccharomyces cerevisiae Are Associated in a Protein Complex," Mol. Cell. Biol. 11(6): 3307-3316 (1991).
Weinstat-Saslow et al., Genomics 18: 709-711 (1993).

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