Wavy interface mixer

Chemistry: analytical and immunological testing – Including sample preparation – Volumetric liquid transfer

Reexamination Certificate

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Details

C436S043000, C436S052000, C436S053000, C436S063000, C436S174000, C422S050000, C422S068100, C422S105000, C422S081000, C422S082000, C422S105000, C137S087010, C137S088000, C137S109000, C137S110000, C137S111000, C137S112000

Reexamination Certificate

active

07416903

ABSTRACT:
The present invention provides methods and apparatus for mixing samples in-line in a microfluidic system, comprising methods of and means for introducing a first fluid sample into a flow-tube at a first end at a first velocity via a first conduit; methods of and means for introducing a second fluid sample into the flow-tube at the first end at a second velocity, the second velocity different from the first velocity, via a second conduit, wherein the first fluid sample and the second fluid sample converge in the flow tube to form an interface; whereby the first fluid sample and the second fluid sample mix at the interface within the flow-tube, wherein fluid flow at the first end of the flow-tube is laminar and fluid flow at a second end of the flow-tube is laminar, and wherein the flow-tube has a constant diameter between the first end and the second end of the flow-tube.

REFERENCES:
patent: 3640822 (1972-02-01), Hrdina
patent: 3698870 (1972-10-01), DeJong
patent: 3921439 (1975-11-01), Burns
patent: 4053282 (1977-10-01), Hach et al.
patent: 4116631 (1978-09-01), Trinel et al.
patent: 4177677 (1979-12-01), Ruzicka et al.
patent: 4224033 (1980-09-01), Hansen et al.
patent: 4253846 (1981-03-01), Smythe et al.
patent: 4399225 (1983-08-01), Hansen et al.
patent: 4661913 (1987-04-01), Wu et al.
patent: 4853336 (1989-08-01), Saros et al.
patent: 4957009 (1990-09-01), Nohl et al.
patent: 5062419 (1991-11-01), Rider
patent: 5080866 (1992-01-01), Petty et al.
patent: 5199386 (1993-04-01), Hubbard
patent: 5221521 (1993-06-01), Hashizume et al.
patent: 5225488 (1993-07-01), Baird et al.
patent: 5250104 (1993-10-01), Berger et al.
patent: 5251662 (1993-10-01), Rubel et al.
patent: 5268147 (1993-12-01), Zabetakis et al.
patent: 5286452 (1994-02-01), Hansen
patent: 5369037 (1994-11-01), Hansen
patent: 5374398 (1994-12-01), Isami et al.
patent: 5395588 (1995-03-01), North et al.
patent: 5407274 (1995-04-01), Woerheide et al.
patent: 5464752 (1995-11-01), Kortright et al.
patent: 5488469 (1996-01-01), Yamamoto et al.
patent: 5504010 (1996-04-01), Mitani et al.
patent: 5532154 (1996-07-01), Brown
patent: 5641457 (1997-06-01), Vardanega et al.
patent: 5694486 (1997-12-01), Shigeeda et al.
patent: 5709468 (1998-01-01), Woerheide et al.
patent: 5710854 (1998-01-01), Myers et al.
patent: 5739036 (1998-04-01), Parris
patent: 5776781 (1998-07-01), Varadanega et al.
patent: 5788927 (1998-08-01), Farrell et al.
patent: 5806471 (1998-09-01), Lin
patent: 5810032 (1998-09-01), Hong et al.
patent: 5824269 (1998-10-01), Kosaka et al.
patent: 5834314 (1998-11-01), Gates et al.
patent: 5895764 (1999-04-01), Sklar et al.
patent: 5958203 (1999-09-01), Parce et al.
patent: 6056001 (2000-05-01), Boyles et al.
patent: 6132685 (2000-10-01), Kercso et al.
patent: 6150180 (2000-11-01), Parce et al.
patent: 6156178 (2000-12-01), Mansfield et al.
patent: 6454945 (2002-09-01), Weigl et al.
patent: 6541213 (2003-04-01), Weigl et al.
patent: 7011791 (2006-03-01), Weigl et al.
patent: 7141429 (2006-11-01), Munson et al.
Deandrade et al., “High Performance Modular Spectrophotometric Flow Cell,”Analyst, v. 116:905-907, 1991.
Hodder, P. S., et al., “Microfabricated Flow Chamber for Fluorescence-Based Chemistries and Stopped-Flow Injection Cytometry,”Analyst, vol. 122, pp. 883-887, (Sep. 1997).
Lindberg et al., “Flow Injection Cytometry: A New Approach for Sample and Solution Handling in Flow Cytometry,”Cytometry14:230-236 (1993).
Nolan, J. P., et al., “A Rapid Mix Flow Cytometer with Subsecond Kinetic Resolution,”Cytometry, vol. 21, pp. 223-229 (1995).
Nolan, J. P., et al., “The Emergence of Flow Cytometry for Sensitive, Real-Time Measurements of Molecular Interactions,”Nature Biotechnology, vol. 16, pp. 633-638 (Jul. 1998).
Pennings et al., “Improved Flow Cytometry of Cellular DNA and RNA by On-Line Reagent Addition,”Cytometry8:335-338 (1987).
Zhao et al., “A Flow Injection Flow Cytometry System for Online Monitoring of Bioreactors,”Biotechnology and Bioengineeringv62:609-617,Analyst.
Zhi ZL, “Segmental Flow-Injection Analysis, A Hybrid Technique of Segmented Continuous-Flow Analysis, a Hybrid Technique of Segmented Continuous-Flow Analysis and Flow-Injection Analysis,”Analysis.
US 5,778,927, 8/1998, G. A. Farrell, et al. (withdrawn).
US 5,778,927, 8/1998, Farrell et al. (withdrawn).

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