Wavelength-specific cytotoxic agents

Details Wavelength-specific cytotoxic agents Wavelength-specific cytotoxic agents

1989-09-28

1992-03-10

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

540145, A61K 3140, C07D48722

Patent

active

050950304

ABSTRACT:
A group of hydro-monobenzoporphyrins "green porphyrins" (Gp) having absorption maxima in the range of 670-780 nanometers is useful in treating disorders or conditions which are subject to hematoporphyrin derivative (HPD) treatment in the presence of light, or in treating virus, cells and tissues generally to destroy unwanted targets. The use of the Gp of the invention permits the irradiation to use wavelengths other than those absorbed by blood. The Gp of the invention may also be conjugated to ligands specific for receptor or to specific immunoglobulins or fragments thereof to target specific tissues or cells for the radiation treatment. Use of these materials permits lower levels of drug to be used, thus preventing side reactions which might destroy normal tissues.

REFERENCES:
patent: 2951600 (1960-09-01), Sharp
patent: 4268947 (1981-05-01), Hile
patent: 4485806 (1984-12-01), Akers
patent: 4500507 (1985-02-01), Wong
patent: 4512762 (1985-04-01), Spears
patent: 4577636 (1986-03-01), Spears
patent: 4649151 (1987-03-01), Dougherty et al.
patent: 4675338 (1987-06-01), Bommer et al.
patent: 4727027 (1988-02-01), Wiesenhahn et al.
patent: 4748120 (1988-05-01), Wiesenhahn et al.
patent: 4753958 (1988-05-01), Weinstein et al.
patent: 4883790 (1989-11-01), Levy et al.
patent: 4920143 (1990-04-01), Levy et al.
Dougherty et al., "Porphyrin Photosensitization", Kessel et al., editors, (1983), Plenum Press, pp. 3-13.
Gregorie et al., Ann. Surg., (1968), 167:827-829.
Diamond et al., Lancet, (1972), 2:1175-1177.
Dougherty et al., Cancer Research, (1978), 38:2628-2635.
Dougherty et al., "The Science of Photo Medicine", (1982), Regan & Parish, editors, pp. 625-638.
Dougherty et al., "Cancer: Principles and Practice of Oncology", (1982), Devita et al., editor, pp. 1836-1844.
Weishaupt et al., Cancer Research, (1976), 36:2326-2329.
Dougherty et al., "Porphyrin Localization and Treatment of Tumors", (1984), pp. 301-314.
Dougherty, CRC Critical Reviews in Oncology/Hematology, (1984), 2(2):83-116.
Mew et al., J. Immunol., (1983), 130(3):1473-1477.
Mew et al., Cancer Research, (1985), 45:4380-4386.
Oseroff et al., Proc. Natl. Acad. Sci. USA, (1986), 83:8744-8748.
Richter et al., J. Natl. Cancer Inst., (1987), 79(6):1327-1332.
Morgan et al., J. Chem. Soc. Chem. Commun., (1984), pp. 1047-1048.
Pangka et al., J. Organic Chem., (1986), 51:1094-1100.
Steele et al., Cancer Immunol. Immunotherapy, (1988), 26(2):125-131.
Wat et al., Prog. Clin. Biol. Res., (1984), 170:351-359.
Levy et al., Lasers Surg. Meth., (1985), 5(2):141.

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