Wavelength-specific cytotoxic agents

Details Wavelength-specific cytotoxic agents Wavelength-specific cytotoxic agents

1987-04-23

1989-11-28

Schenkman, Leonard

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

A61K 3166

Patent

active

048837903

ABSTRACT:
A group of hydro-monobenzoporphyrins "green porphyrins" (Gp) having absorption maxima in the range of 670-720 nanometers is useful in treating disorders which are subject to hematoporphyrin derivative (HPD) treatment in the presence of light. The use of the Gp of the invention permits the irradiation to comprise wavelengths other than those absorbed by blood. The Gp of the invention may also be conjugated to receptor ligands or to specific immunoglobulins or fragments thereof to target specific tissues or cells for the radiation treatment. Use of these materials permits lower levels of drug to be used, thus preventing side reactions which might destroy normal tissues.

REFERENCES:
patent: 2951800 (1960-09-01), Sharp
patent: 4649151 (1987-03-01), Dougherty et al.
patent: 4675338 (1987-06-01), Bommer et al.
Morgan et al., J. Chem. Soc., Chem. Commun., 1984, pp. 1047-1048.
Richter et al.-JNCI, vol. 79, No. 9, 12-1983, pp. 1327-1332.
Pangka et al., J. Organic Chem., 51:1094, 1986.

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