Waveguide sensor with input and reflecting gratings and its use

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

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435 792, 435 793, 435 794, 435288, 435291, 422 8211, 356 731, 436172, G01N 3353, G01N 2100, G01N 2176, C12M 140

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active

050810120

ABSTRACT:
Waveguides suitable for use in optical assay techniques are described, as well as methods of assay employing such waveguides. The waveguide comprises an input grating structure to couple excitation radiation into the waveguide, a reflecting grating structure to reflect the excitation radiation propagating within the waveguide, and a transduction region located between the two grating structures, whereby during use the excitation radiation traverses the transduction region at least twice.

REFERENCES:
patent: 4815843 (1989-08-01), Tiefenthaler et al.
patent: 4880752 (1989-11-01), Keck et al.
Bohn, P. W. in Trends in Anal. Chem., 6(9), pp. 223-233 (1987).
Tiefenthaler and Lukosz in Optics Letters, 10(4), pp. 137-139 (1984).
Fisher Catalog `86 Cat. #08-757-XXX.

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