Waveguide immunosensor with coating chemistry and providing enha

Details Waveguide immunosensor with coating chemistry and providing enha Waveguide immunosensor with coating chemistry and providing enha

1996-04-30

1998-12-08

Chin, Christopher L.

Chemistry: analytical and immunological testing

Involving an insoluble carrier for immobilizing immunochemicals

356317, 356318, 356246, 385 12, 385129, 385130, 385131, 422 55, 422 57, 422 58, 422 8205, 422 8208, 422 8211, 4352871, 4352872, 4352879, 4352887, 435808, 436164, 436165, 436527, 436805, G01N 33543, G01N 33552

Patent

active

058468420

ABSTRACT:
Methods and apparatus for evanescent light fluoroimmunoassays are disclosed. The apparatus employs a planar waveguide and optionally has multi-well features and improved evanescent field intensity. The preferred biosensor and assay method have the capture molecules immobilized to the waveguide surface by site-specific coupling chemistry. Additionally, the coatings used to immobilize the capture molecules provide reduced non-specific protein adsorption.

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