Water-stabilized biopolymeric implants

Prosthesis (i.e. – artificial body members) – parts thereof – or ai – Implantable prosthesis

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623 1, 530356, 424423, 424424, 523113, A61F 202

Patent

active

056742908

ABSTRACT:
A method of treating a reconstituted biopolymeric implant which includes the steps of exposing the implant to an aqueous environment so that a final water content of the implant ranges from 5% by weight to a maximal water absorption capacity; and sealing the hydrated implant in a gamma ray-penetrable but bacteria- or virus-impenetrable material. Also disclosed is an implant preparation obtained by the above method.

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Cheung et al., "The Effect of .gamma.-Irradiation on Collagen Molecules, Isolated .alpha.-Chains, and Crosslinked Native Fibers", Journal of Biomedical Materials Research, 24:581-589, 1990.
Li et al., "Gamma-Irradiation of Reconstituted Collagen Matrices With Diffrent Water Contents: Implications in Implantable Device Devel.," The 20th Annual Meeting of the Society for Biomaterials, Apr. 5-9, 1994.
Liu et al, "The Effect of Gamma Irradiation on Injectable Human Amnion Collagen", Journal of Biomedical Research, 23:833-844, 1989.
Urry et al., "Irradiation Crosslinking of the Polytetrapeptide of Elastin and Compounding to Dacron to Produce a Potential Prosthetic . . . ", Journal of Biomedical Materials Research, 16:11-16, 1982.

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