Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving blood clotting factor
Patent
1987-06-18
1989-01-31
Kepplinger, Esther M.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving blood clotting factor
435 23, 435184, 435 69, C12Q 156, C12Q 138, C12N 999
Patent
active
048015342
ABSTRACT:
Water soluble xanthylium derivative substrates of rhodamine 110 and rhodol permit spectrophotometric and fluorescent measurements of trypsin-like enzymes without the addition of organic solvent additives and/or special water solubilizing agents. These novel substrates exhibit increased sensitivity for determining low levels of activity of trypsin-like enzymes such as proteolytic enzymes, cofactors, activators, antiactivators, and inhibitors. These substrates can be substituted for fibrinogen to monitor the pathways of blood coagulation.
REFERENCES:
patent: 4275153 (1981-06-01), Gargiulo et al.
patent: 4279810 (1981-07-01), Claeson et al.
patent: 4294923 (1981-10-01), Smith et al.
patent: 4336186 (1982-06-01), Gargiulo et al.
patent: 4557862 (1985-12-01), Mangel et al.
Leytus et al., Biochimica et Biophysica Acta, vol. 788, pp. 74-86 (1984).
Leytus et al., Rhodamine-Based Compounds as Fluorogenic Substrates for Serine Proteinases, Biochem. Journal (1983) 209, pp. 299-307.
Leytus et al., New Class of Sensitive and Selective Fluorogenic Substrates for Serine Proteinases, Biochem. Journal (1983) 215, pp. 253-260.
Batsakis and Savory (Eds.), Critical Reviews in Clinical Laboratory Sciences (1981), pp. 25-84.
Jaffe Gerald E.
Mitchell Gary A.
Solorzano Marilyn M.
Coulter Electronics Inc.
Hibnick Gerald R.
Kepplinger Esther M.
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