Water soluble xanthylium derivatives substrates

Details Water soluble xanthylium derivatives substrates Water soluble xanthylium derivatives substrates

1985-05-28

1987-09-15

Phillips, Delbert K.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

6 to 7 amino acid residues in defined sequence

530802, 435 23, C07K 706, C12Q 138

Patent

active

046940707

ABSTRACT:
Water soluble xanthylium derivative substrates of rhodamine 110 and rhodol permit spectrophotometric and fluorescent measurements of trypsin-like enzymes without the addition of organic solvent additives and/or special water solubilizing agents. These novel substrates exhibit increased sensitivity for determining low levels of activity of trypsin-like enzymes such as proteolytic enzymes, cofactors, activators, antiactivators, and inhibitors. These substrates can be substituted for fibrinogen or monitor the pathways of blood coagulation.

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patent: 4294923 (1981-10-01), Smith et al.
patent: 4336186 (1982-06-01), Gargiulo et al.
patent: 4557862 (1985-12-01), Mangel et al.
Leytus et al., Rhodamine-Based Compounds as Fluorogenic Substrates for Serine Proteinases, Biochem. Journal, (1983), 209, pp. 299-307.
Leytus et al., New Class of Sensitive and Selective Fluorogenic Substrates for Serine Proteinases, Biochem. Journal, (1983), 215, pp. 253-260.
Batsakis and Savory (editors), Critical Reviews in Clinical Laboratory Sciences, (1981), pp. 25-84.
Duncan et al., A Clinical Evaluation of Automated Chromogenic Tests as Substitutes for Conventional Prothrombin Time and Activated Partial Thromboplastin Time Tests, Clin. Chem., vol. 31, No. 6, (1985), pp. 853-855.

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