Water soluble tri-substituted 1,2-dioxetane compounds and assay

Details Water soluble tri-substituted 1,2-dioxetane compounds and assay Water soluble tri-substituted 1,2-dioxetane compounds and assay

1996-11-08

1998-02-24

Owens, Amelia A.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549214, 549332, 549510, C07F 928, C07D32100

Patent

active

057213704

ABSTRACT:
Stable, enzymatically triggered chemiluminescent 1,2-dioxetanes with improved water solubility and storage stability are provided. Dioxetanes further substituted with two or more water-solubilizing groups disposed on the dioxetane structure and an additional fluorine atom or lower alkyl group provide superior performance by eliminating the problem of reagent carryover when used in assays performed on capsule chemistry analytical systems. These dioxetanes display substantially improved stability on storage. Compositions comprising these dioxetanes, a non-polymeric cationic surfactant enhancer and optionally a fluorescer, for providing enhanced chemiluminescence are also provided.

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