Water soluble transplatinum complexes with anti-cancer activity

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heavy metal containing doai

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556137, 546 5, 546 6, 548104, 548105, 548402, 548403, A61K 3128, C07F 1500

Patent

active

060018720

ABSTRACT:
The present invention relates to the treatment of tumors with a novel water soluble trans-platinum coordination compound having the general structural formula [PtBX.sub.m (NR*.sub.3)] where B is a planar, heterocyclic ring containing at least one nitrogen atom, and a pendant chelating group; and X is an anionic ligand; and R* is hydrogen or a lower alkyl.

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Sigel, Astrid and Sigel, Helmut, Metal Ions in Biological Systems, 1996, vol. 32, pp. 603-639.

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