Organic compounds -- part of the class 532-570 series – Organic compounds – Unsubstituted hydrocarbyl chain between the ring and the -c-...
Patent
1998-02-26
1999-11-30
Shah, Mukund J.
Organic compounds -- part of the class 532-570 series
Organic compounds
Unsubstituted hydrocarbyl chain between the ring and the -c-...
534 10, 534 11, 534 15, 540145, 540474, C07D48722, C07F 96524
Patent
active
059945354
ABSTRACT:
The present invention is directed to methods for synthesizing water soluble hydroxy-substituted texaphyrins retaining lipophilicity. The synthesis comprises condensing a diformyltripyrrole with an ortho-phenylenediamine to give a nonaromatic texaphyrin having at least one hydroxy substituent, and oxidizing the condensation product to form an aromatic texaphyrin metal complex having at least one hydroxy substituent. These expanded porphyrin-like macrocycles may be used for magnetic resonance imaging and for photodynamic therapy in the treatment of atheroma and tumors.
REFERENCES:
patent: 5733903 (1998-03-01), Sessler
Hemmi Gregory W.
Mody Tarak D.
Sessler Jonathan L.
Board of Regents , The University of Texas System
Larson Jacqueline S.
Lowin David A.
Shah Mukund J.
Sripada Pavanaram K.
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