Water soluble tetrapyrollic photosensitizers for...

Details Water soluble tetrapyrollic photosensitizers for... Water soluble tetrapyrollic photosensitizers for...

2009-02-19

2010-10-26

Sullivan, Daniel M (Department: 1621)

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

Magnetic imaging agent

C424S009610, C514S279000, C514S410000

Reexamination Certificate

active

07820143

ABSTRACT:
A tetrapyrollic photosensitizer compound having at least one pendant —CH2CH2CON(CH2CON(CH2COOH)2)2or —N(CH2COOH)2group or esters thereof said tetrapyrollic compound being a chlorin, bacteriochlorin, porphyrin, pyropheophorbide, purpurinimide, or bacteriopurpurinimide. Desirably the compound has the formula:or a pharmaceutically acceptable derivative thereof, wherein R1-R8and R10are various substituents and R9is substituted or unsubstituted —CH2CH2CON(CH2CON(CH2COOH)2)2; or —N(CH2COOH)2. The invention also includes a method of treatment by photodynamic therapy by treatment with light after injecting the compound and a method of imaging by fluorescence after injection of the compound.

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