Water-soluble SHPs as novel alkylating agents

Details Water-soluble SHPs as novel alkylating agents Water-soluble SHPs as novel alkylating agents

2005-02-15

2005-02-15

Tate, Christopher R. (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C514S013800, C514S014800, C514S015800, C514S016700, C514S017400, C514S018700, C514S019300, C530S324000, C530S325000, C530S326000, C530S327000, C530S328000, C530S329000, C530S330000

Reexamination Certificate

active

06855695

ABSTRACT:
The present invention relates to compounds according to the structure (I):Where R is —CH3or —CH2CH2Cl; R′ is C1-C7alkyl or —CH2CH2Cl; R2or R4is OPO3H2, NO2, OCO(Glu-OH), NHCO(Glu-OH), NHR7and unassigned groups of R2, R3, R4, R5and R6are, independently H, F, Cl, Br, I, OH, OPO3H2, OCH3, CF3, OCF3, NO2, CN, SO2CH3, SO2CF3, COCH3, COOCH3, SCH3, SF5, NH2, NHR7, N(CH3)2, OPO3H2, or a C1-C7 alkyl group with the proviso that when any two of unassigned groups of R2, R3, R4, R5or R6are other than H, the other two of unassigned groups of R2, R3, R4, R5or R6are H. R7is H or polyglutamyl as described. Phosphoric acid and glutamic acid can be a free acid or pharmaceutically acceptable salt thereof.

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