Water soluble rapamycin esters

Details Water soluble rapamycin esters Water soluble rapamycin esters

1998-03-23

1999-09-21

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

A61K 3133

Patent

active

059554576

ABSTRACT:
A compound of the structure ##STR1## wherein R.sup.1 and R.sup.2 are each, independently, hydrogen or --COCH.sub.2 --S--CH.sub.2 CH.sub.2 --O--CH.sub.2 --(CH.sub.2 OCH.sub.2).sub.n --CH.sub.2 --O--CH.sub.2 CH.sub.2 --OCH.sub.3 ; and n=8-450; with the proviso that R.sup.1 and R.sup.2 are not both hydrogen, which is useful as an immunosuppressive, antiinflammatory, antifungal, antiproliferative, and antitumor agent.

REFERENCES:
patent: 3929992 (1975-12-01), Sehgal et al.
patent: 3993749 (1976-11-01), Sehgal et al.
patent: 4316885 (1982-02-01), Rakhit
patent: 4375464 (1983-03-01), Sehgal et al.
patent: 4401653 (1983-08-01), Eng
patent: 4650803 (1987-03-01), Stella et al.
patent: 4885171 (1989-12-01), Surendra et al.
patent: 5023262 (1991-06-01), Caufield et al.
patent: 5023263 (1991-06-01), Von Burg
patent: 5023264 (1991-06-01), Caufield et al.
patent: 5078999 (1992-01-01), Warner et al.
patent: 5080899 (1992-01-01), Sturm et al.
patent: 5091389 (1992-02-01), Ondeyka et al.
patent: 5100883 (1992-03-01), Schiehser
patent: 5100899 (1992-03-01), Calne
patent: 5102876 (1992-04-01), Caufield
patent: 5118677 (1992-06-01), Caufield
patent: 5118678 (1992-06-01), Kao et al.
patent: 5120842 (1992-06-01), Failli et al.
patent: 5130307 (1992-07-01), Failli et al.
patent: 5138051 (1992-08-01), Hughes et al.
patent: 5151413 (1992-09-01), Caufield et al.
patent: 5169851 (1992-12-01), Hughes et al.
patent: 5177203 (1993-01-01), Failli et al.
patent: 5194447 (1993-03-01), Kao
patent: 5221670 (1993-06-01), Caufield
patent: 5233036 (1993-08-01), Hughes
patent: 5258389 (1993-11-01), Goulet et al.
patent: 5260300 (1993-11-01), Hu
patent: 5302584 (1994-04-01), Kao et al.
patent: 5321009 (1994-06-01), Baeder et al.
patent: 5362718 (1994-11-01), Skotnicki et al.
patent: 5378696 (1995-01-01), Caulfield
patent: 5385908 (1995-01-01), Nelson et al.
patent: 5385909 (1995-01-01), Nelson et al.
patent: 5385910 (1995-01-01), Ocain et al.
patent: 5387589 (1995-02-01), Kulkarni
patent: 5389639 (1995-02-01), Failli et al.
patent: 5391730 (1995-02-01), Skotnicki et al.
patent: 5463048 (1995-10-01), Skotnicki et al.
patent: 5491231 (1996-02-01), Nelson et al.
patent: 5496832 (1996-03-01), Armstrong
patent: 5516770 (1996-05-01), Waranis et al.
patent: 5516781 (1996-05-01), Morris et al.
Venzina, C., J. Antibiot. 28:721 (1975).
Sehgal, S.N., J. Antibiot. 28:727 (1975).
Baker, H.J., Antibiot. 31:539 (1978).
Martel, R.R., Can. J. Physiol. Pharmacol. 55:48 (1977).
Staruch, M.J., FASEB 3:3411 (1989).
Dumont, F.J., FASEB 3:5256 (1989).
Calne, R.Y., Lancet 1183 (1978).
Morris, R.E., Med. Sci. Res. 17:877 (1989).
Baeder, W.L., Fifth Int. Conf. Inflamm. Res. Assoc. 121 (Abstract) (1990).
Meiser, B.M., J. Heart Lung Transplant. 11 (pt. 2):197 (1992).
Stepkowski, S.M., Transplantation Proc. 23:507 (1991).

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