Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert
Patent
1995-08-03
1997-12-23
Azpuru, Carlos A.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Implant or insert
424430, 424435, 424436, 424437, 424443, 5147723, 514777, 514778, 514780, 514781, 514782, A61F 606, A61F 902, A61K 970, A61K 4730
Patent
active
057004781
DESCRIPTION:
BRIEF SUMMARY
This application is a 371 of PCT/US94/09305 filed Aug. 19, 1994.
BACKGROUND
1. Technical Field
This invention relates to mucoadhesives and to mucoadhering devices. Additionally and particularly this invention relates to compositions that adhere both to mucosal surfaces and to a variety of materials that may constitute a part of a device or prosthesis to be held in a body cavity, such as the oral cavity or the vagina or the rectum, that has a mucosal lining. Additionally this invention relates to mucoadhering devices useful for controlled release of substances within a body cavity that has a mucosal lining, such as for example the oral cavity, and particularly to such devices that are provided with adhesives suitable for fixation of the device within the oral cavity. Additionally and particularly this invention relates to administering breath-freshening agents, and particularly mint odorants, into the oral cavity of a person over extended time periods, for freshening the person's breath. And additionally this invention relates to administering agents into a person's oral cavity over extended times for relief of sore throat pain and cough.
2. Background Art
For a number of practical purposes, it can be useful to affix a device within a mucosa-lined body cavity, such as the oral cavity, the vaginal cavity, or the rectal cavity. Devices that may usefully be positioned within a mucous-lined body cavity include, for example, denture prostheses and devices for controlled release of medicaments.
In one approach for such purposes, the device can be affixed to a mucosal surface of the body cavity by means of an adhesive. Various bioadhesives have been proposed for use in establishing adhesive contact with mucosal surfaces.
For example, U.S. Pat. No. 4,713,243 describes an extruded film for use in controlled release of medicaments, including a water-soluble or swellable polymer matrix capable of adhering to a wet mucous surface, made up of 40-95% hydroxy propyl cellulose, 5-60% poly(ethylene oxide), optionally up to 10% of a water-insoluble polymer (ethyl cellulose, propyl cellulose, polyethylene or polypropylene) and 2-10% of a plasticizer introduced to facilitate processing, and containing the medicament. There is no disclosure in the '243 patent that this composition can adhere to materials that may be used in oral prosthesis or other devices, or that it is pressure-sensitive.
Adhesives for affixing dental prostheses in the mouth are conventionally in the form of pastes or creams. These are messy and inconvenient to use, and generally adhere poorly or not at all after extended periods.
U.S. Pat. No. 4,529,748 describes a dental prosthesis adhesive in powder form, in which the particles are made from carboxy methyl cellulose, poly(ethylene oxide), poly(acrylic acid), and karaya gum. Some portion of the particles are coated with a cellulose or acrylate polymer film that dissolves slowly in saliva.
U.S. Pat. No. 4,948,580 describes a bioadhesive composition for delivery of anti-bacterials, including a copolymer of ("PVME/MA"), and gelatin, dispersed in an ointment base.
International Patent Publication No. WO 91 16041 (Oct. 31, 1991) describes a pharmaceutical composition, to be held under the tongue, in the form of a thin starch wafer capable of molding to the contours of the sub-lingual cavity, thereby allowing for absorption of medicaments contained within the wafer through the sub-lingual mucosa.
Conventionally, medications for treatment for relief of sore throat and cough are provided in a form such as a lozenge to be held in the mouth of the person being treated, or in the form of a mouthwash or spray. These forms of delivery work generally by shedding the medication into the saliva, which bathes the tissues of the oral cavity and throat as it passes posteriorly toward the esophagus. Such forms remain in the oral cavity only for short periods of time, generally in the range up to about 10 or 20 minutes, and they cannot provide for delivery of the medication to the oral cavity over extended times. In these fo
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Biegajski James E.
Scott Ann M.
Venkatraman Subbu S.
Azpuru Carlos A.
Cygnus Inc.
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