Water soluble polymer-tacrolimus conjugated compounds and proces

Details Water soluble polymer-tacrolimus conjugated compounds and proces Water soluble polymer-tacrolimus conjugated compounds and proces

1998-04-28

1999-07-13

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

540456, A61K 31395, A61K 31695, C07D49816, C07F 704

Patent

active

059227290

ABSTRACT:
The present invention relates to a tacrolimus conjugated compound represented by formula (I): ##STR1## in which R.sub.1 and R.sub.2 independently of one another represent hydrogen or a group of formula --CO--CH.sub.2 --X--(CH.sub.2 CH.sub.2 --O)n--CH.sub.3 wherein n denotes an integer of 10 to 460, and

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J. Am. Chem. Soc., 109(16):5031-5032 (1987).

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