Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1994-08-16
1996-10-22
Kight, III, John
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
514 54, 514 59, 536 65, 536 111, 536112, 536123, 5361231, 536124, 536127, A61K 3170, C07H 106, C07G 1100, C08B 3702
Patent
active
055676855
ABSTRACT:
A method for producing a substantially stable water-soluble polysaccharide conjugate of a polyene antibiotic is described. The method comprises the following steps: (a) activating the polysaccharide to a dialdehyde by periodate oxidation; (b) purifying the dialdehyde from interfering anions and by-products; (c) coupling the polyene to the purified dialdehyde by Schiff base formation to form the conjugate; and (d) purifying the conjugate. In a preferred embodiment, the conjugate of step (c) is reduced to an amine conjugate by a reducing agent prior to purification. Also described are imine and amine polysaccaride conjugates of the polyene Nystatin.
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Benita Shimon
Domb Abraham J.
Linden Galina
Polacheck Itzhack
Kight III John
White Everett
Yissum Research Development Company of the Hebrew University of
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