Water-soluble phenylpyridazine derivative and medicine...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C514S247000, C514S252020, C514S252030, C544S114000, C544S238000, C544S239000

Reexamination Certificate

active

10544881

ABSTRACT:
A phenylpyridazine derivative represented by the formula (1):Wherein, R1, R2, R3, X, Y, Z and n have the same meaning as defined in the specification; or a salt thereof, or a medicine containing the compound. The present invention provides water-soluble phenylpyridazine derivatives and medicines containing them, which have excellent inhibitory activity against interleukin-β production, high water solubility and high oral absorbability.

REFERENCES:
patent: 4954518 (1990-09-01), Takano et al.
patent: 6348468 (2002-02-01), Ohkuchi et al.
patent: 6403586 (2002-06-01), Ohkuchi et al.
patent: 6664256 (2003-12-01), Ohkuchi et al.
patent: 6680316 (2004-01-01), Ohkuchi et al.
patent: 6861428 (2005-03-01), Kyotani et al.
patent: 6869954 (2005-03-01), Kyotani et al.
patent: 2002/0123496 (2002-09-01), Ohkuchi et al.
patent: 2004/0147516 (2004-07-01), Ohkuchi et al.
patent: 2005/0065155 (2005-03-01), Ohkuchi et al.
patent: 2005/0085480 (2005-04-01), Kyotani et al.
patent: 2 333 643 (1974-01-01), None
patent: 0 376 288 (1990-07-01), None
patent: 07-069894 (1995-03-01), None
patent: 7-503017 (1995-03-01), None
patent: 97/05878 (1997-02-01), None
patent: 98/41511 (1998-09-01), None
patent: 99/10331 (1999-03-01), None
patent: 99/10332 (1999-03-01), None
patent: 99/25697 (1999-05-01), None
patent: 99/44995 (1999-09-01), None
patent: 00/24719 (2000-05-01), None
patent: 00/50408 (2000-08-01), None
patent: 02/04427 (2002-01-01), None
patent: 03/027077 (2003-04-01), None
patent: 2004/078751 (2004-09-01), None
Chalmers (TiPS vol. 17, pp. 166-172 Apr. 1996).
Chang et al. Am. J. Respir. Crit. Care Med, vol. 156, 1230-1234 (1997).
Assuma et al. J. Immuno. 169:403-409 (1998).
Wilson, et al. J. Antimicrobial Chemotherapy 41, Suppl. A:51-63 (1998).
Chernow et al. Chest 112(6) 1997.
Li et al. Cell 80:401-411 (1995).
Molina et al. J. Clin. Inves. 84:733-737.
Arend et al. Arthritis and Rheumatism, 38(2):151-160 (1995).
Rossenwasser J. Alergy Clin. Immuno., 102(3) Sep. 1998.
Romas et al. Osteopros Int (1997), 7(Suppl. 3):S47-S53.
Ohzeki et al. “Antirheumatic activities of KE-298, having an effect on IL-1 (1stReport)”, The Japan Inflammation Academy, 11thsession, with English translation 1990.
Casini-Raggi et al. “Anti-inflammatory Effects of CGP 47969A, a Novel Inhibitor of Proinflammatory Cytokine Synthesis, in Rabbit Immune Colitis”, Gastroenterology, vol. 109, pp. 812-818 1995.
Tanaka et al. “Hydroxyindole derivatives as inhibitors of IL-1 generation. II. Synthesis and pharmacological activities of (E)-3-(7-hydroxy-6-methoxyindole-4-yl)-2-methylpropenoic acid derivatives”, Eur J Med Chem, vol. 31, pp. 187-198 1996.
Ku et al. “Interleukin-1beta Converting Enzyme Inhibition Blocks Progression of Type II Collagen-induced Arthritis in Mice”, Cytokine, vol. 8, No. 5, pp. 377-386 1996.
Nannini et al. “Synthesis and pharmacological activity of some 5, 6-diphenyl-pyridazines”, Eur J Med Chem, vol. 14, pp. 53-60 1979.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Water-soluble phenylpyridazine derivative and medicine... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Water-soluble phenylpyridazine derivative and medicine..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Water-soluble phenylpyridazine derivative and medicine... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3749890

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.