Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2005-03-22
2005-03-22
Bernhardt, Emily (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C514S236500, C514S252020, C514S252030, C544S114000, C544S238000, C544S239000
Reexamination Certificate
active
06869954
ABSTRACT:
Compounds having the formula (1):wherein R1represents an alkyl or alkenyl group, R2and R3each independently represent a hydrogen atom or an alkyl, hydroxyalkyl, dihydroxyalkyl or alkynyl group, or R2and R3may be fused together with the adjacent nitrogen atom to form a substituted or unsubstituted, nitrogen-containing, saturated heterocyclic group, X, Y and Z each independently represent a hydrogen atom, an alkyl group, a halogen atom or the like, and n stands for an integer of from 1 to 5; and also to medicinal compositions containing them. These compounds have inhibitory activity against IL-1β production, high water solubility and good oral absorbability.
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Livingston, Journal of Cellular Biochemistry, vol. 64, p. 19-26 (1997).
Kitamura Takahiro
Koshi Tomoyuki
Kyotani Yoshinori
Sato Seiichi
Shigyo Hiromichi
Bernhardt Emily
Kowa Co. Ltd.
Oblon & Spivak, McClelland, Maier & Neustadt P.C.
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