Water-soluble peptides affecting gonadal function

Details Water-soluble peptides affecting gonadal function Water-soluble peptides affecting gonadal function

1979-06-11

1981-01-13

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Reduced antigenicity, reduced ability to bind complement, or...

2601125LH, A61K 3700, C07C10352

Patent

active

042449464

ABSTRACT:
[im-Bzl D-His.sup.6 ]LRF and [D-His.sup.6 (im-Bzl), Pro.sup.9 -NEt]LRF exhibit hydrophillicity comparable to that of LRF and act as superagonists exhibiting potencies, respectively, about 12 and more than 200 times that of LRF. The peptides or their nontoxic salts can be administered by intravenous subcutaneous, sublingual, oral, intravaginal, intranasal or rectal routes. The peptides can be used to regulate fertility in male and female mammals, including human beings.

REFERENCES:
patent: 4010125 (1977-03-01), Schally et al.
patent: 4018726 (1977-04-01), Schally et al.
patent: 4034082 (1977-07-01), Johnson et al.
patent: 4086219 (1978-04-01), Wittle et al.
J. Rivier, et al., "Peptides", 1976, pp. 427-451.

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