Water-soluble non-antigenic polymer linkable to biologically act

Details Water-soluble non-antigenic polymer linkable to biologically act Water-soluble non-antigenic polymer linkable to biologically act

1998-12-29

2000-09-05

Sellers, Robert E.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Conjugate or complex

4241781, 525 541, 525 5411, 525403, 525408, 5303911, 530395, 530403, 530405, 530408, A61K 39395, A61K 3944, C08G 65331, C08G 65332, C08G 65333

Patent

active

061139068

ABSTRACT:
Branched, substantially non-antigenic polymers are disclosed. Conjugates prepared with the polymers and biologically active molecules such as proteins and peptides demonstrate extended circulating life in vivo. Substantially fewer sites on the biologically active material are used as attachment sites. Methods of forming the polymer, conjugating the polymers with biologically active moieties and methods of using the conjugates are also disclosed.

REFERENCES:
patent: 4101380 (1978-07-01), Rubinstein et al.
patent: 4179337 (1979-12-01), Davis et al.
patent: 4275000 (1981-06-01), Ross
patent: 4680338 (1987-07-01), Sundoro
patent: 4766106 (1988-08-01), Katre et al.
patent: 4846548 (1989-07-01), Klainer
patent: 4889916 (1989-12-01), Packard et al.
patent: 4904582 (1990-02-01), Tullis
patent: 5091176 (1992-02-01), Braatz et al.
patent: 5091542 (1992-02-01), Ahlem et al.
patent: 5093531 (1992-03-01), Sano et al.
patent: 5122614 (1992-06-01), Zalipsky
patent: 5183660 (1993-02-01), Ikeda et al.
patent: 5214131 (1993-05-01), Sano et al.
patent: 5219564 (1993-06-01), Zalipsky et al.
patent: 5229490 (1993-07-01), Tam
patent: 5252714 (1993-10-01), Harris et al.
patent: 5281698 (1994-01-01), Nitecki
patent: 5298643 (1994-03-01), Greenwald
patent: 5321095 (1994-06-01), Greenwald
patent: 5349001 (1994-09-01), Greenwald et al.
patent: 5382657 (1995-01-01), Karasiewicz et al.
patent: 5514379 (1996-05-01), Weissieder et al.
patent: 5543158 (1996-08-01), Gref et al.
patent: 5643575 (1997-07-01), Martinez et al.
patent: 5681567 (1997-10-01), Martinez et al.
patent: 5919455 (1999-07-01), Greenwald et al.
patent: 5932462 (1999-08-01), Harris et al.
Wie et al (1981) Int. Arch. Allergy Appl. Immun. 64:84-99.
Savoca et al (1979) Biochim. Biophys. Acta 578:47-53.
Sehron (1991) Int. Arch. Allergy Appl. Immunol. 94:11-20.
Nucci et al (1991) Advanced Drug Delivery Reviews 6:133-151.
Kanuf et al., "Relationship of Effective Molecular Size:," J Biol Chen. 263:15064-70 (1994).
Nathan et al, "Polyethylene Gylcol-Lysine Copolymers:," Polymers Pelprnts 31:213-214(1992).
Monfardini, C., et al., A Branched Monomethoxypoly (ethylene glycol) for Protein Modification, bioconjugate Chemistry, vol. 6, No. 1, pp. 62-69 (1995).
Yamasaki, N., et al., Novel Polyethylene Glycol Derivatives for Modification of Proteins, Agric. Biol. Chem. 52(8), pp. 2125-2127 (1988).
Yamasaki, N. et al., "Some Properties of Ricin D Modified with a Methoxypolyethylene Glycol Derivative" Agric. Biol. Chem., 54(10) 2635-2640, (1990).
Kodera, Y. et al. "Chemical Modification of L-Asparaginase With a Comb-Shaped-Copolymer of Polyethylene Glycol Derivative and Maleic Anhydride", Biochemical and Biophysical Research Communications, vol. 184, No. 1, 1992Apr. 15, 1992, pp. 144-148.
Bogdanov, A. et al. "A New Marcomolecul as a Contrast Agent for MR Angiography: Preparation, Properties, and Animal Studies" Radiology 187: 701-706 (1993) Mailed May 20, 1993.
Nishimura et al, Enzyme 26, pp. 49-53 (1981).
Kimura et al, Proceeding of the Society for Experimental Biology and Medicine, 188, pp. 364-369 (1988).
Zalipsky et al, Eur. Polym. J., vol. 19, No. 12, pp. 1177-1183, (1983).
Ouchi et al, Drug Design and Discovery, vol. 9, pp. 93-105 (1992).
The Journal of Biological Chemistry vol. 263, No. 29, Issue of Oct. 15, pp. 15064, 15070 (1988).
Eur. Polym. J. vol. 19, No. 12, pp. 1177-1183 (1983).
Biotechnology and Applied Biochemistry 9. 258-268 (1987).
Journal of Controlled Release 10 (1989) 145-154 (1989).
Advanced Drug Delivery Reviews 6 (1991) 133-151.
Cancer Biochem. Biophys. (1984) vol. 7 pp. 175-186.
Polmer Bulletin 18. 487-493 (1987).
Journal of Polymer Science: Polymer Chemistry Edition. vol. 22 pp. 341-352 (1984).
Int. Arch Allergy Appl. Immun. 64:84-99 (1981).

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