Chemistry of inorganic compounds – Sulfur or compound thereof – Binary compound
Reexamination Certificate
2011-07-12
2011-07-12
Vanoy, Timothy C (Department: 1734)
Chemistry of inorganic compounds
Sulfur or compound thereof
Binary compound
C423S566100, C977S774000, C252S30160R, C252S30160S, C252S30140S, C252S30140F
Reexamination Certificate
active
07976819
ABSTRACT:
An economic, direct synthetic method for producing water soluble QDs that are ready for bioconjugation is provided. The method can produce aqueous QDs with emission wavelengths varying from 400 nm to 700 nm. Highly luminescent metal sulfide (MS) QDs are produced via an aqueous synthesis route. MS QDs are capped with thiol-containing charged molecules in a single step. The resultant MS QDs exhibit the distinctive excitonic photoluminescence desired of QDs and can be fabricated to avoid undesirable broadband emissions at higher wavelengths. This provides a significant improvement over the present complex and expensive commercial processes for the production of QDs. The aqueous QDs are stable in biological fluids over a long period of time. In addition, nontoxic ZnS QDs have been produced with good photoluminescence properties by refluxing the ZnS QD suspensions over a period of time.
REFERENCES:
patent: 4751200 (1988-06-01), Gmitter et al.
patent: 5747180 (1998-05-01), Miller et al.
patent: 5985353 (1999-11-01), Lawton et al.
patent: 6251303 (2001-06-01), Bawendi et al.
patent: 6333110 (2001-12-01), Barbera-Guillem
patent: 6350515 (2002-02-01), Lawton et al.
patent: 6426513 (2002-07-01), Bawendi et al.
patent: 6444143 (2002-09-01), Bawendi et al.
patent: 6468808 (2002-10-01), Nie et al.
patent: 6576291 (2003-06-01), Bawendi et al.
patent: 6623559 (2003-09-01), Huang
patent: 7151047 (2006-12-01), Chan et al.
patent: 7214428 (2007-05-01), Naasani
patent: 7335345 (2008-02-01), Shih et al.
patent: 7597870 (2009-10-01), Shih et al.
patent: 7824653 (2010-11-01), Shih et al.
patent: 2007/0042576 (2007-02-01), Chan et al.
Mark L. Brongersma, Nanoshells: gifts in a gold wrapper, Nature Materials, vol. 2, May 2003.
Sharron G. Penn, Lin He and Michael J. Natan, Nanoparticles for bioanalysis, Current Opinion in Chemical Biology 2003, 7:609-615.
Sabrina Foglia, Lorenza Suber, Marcofabio Righini, Size tailoring of CdS nanoparticles by different colloidal chemical techniques, Colloids and Surfaces, A: Physicochemical and Engineering Aspects 177 (2001) 3-12.
Caroline Seydel, Quantom Dots Get Wet, Science, vol. 300, Apr. 4, 2003, pp. 80-81.
B.O. Dabbousi, J. Rodriguez-Viejo, F.V. Mikulec, J.R. Heine, H. Mattoussi, R. Ober, K.F. Jensen and M.G. Bawendi, (CdSe)ZnS Core—Shell Quantom Dots: Sythesis and Characterization of a Size Series of Highly Luminescent Nanocrystallites, J. phys. Chem. B, 1997, 101, 9463-9475.
Marcel Bruchez Jr., Mario Moronne, Peter Gin, Shimon Weiss, A. Paul Alivisatos, Semiconductor Nanocrystals as Fluorescent Biological Labels, Science, vol. 281, Sep. 25, 1998, 2013-2016.
Daniele Gerion, Fabien Pinaud, Shara C. Williams, Wolfgang J. Parak, Daniela Zanchet, Shimon Weiss and Paul Alivisatos, Synthesis and Properties of Biocompatible Water-Soluble Silica-Coated CdSe/ZnS Semiconductor Quantum Dots, J. Phys Chem B, 2001, 105, 8861-8871.
Mark Green, Robin Taylor and Gareth Wakefield, The synthesis of luminescent adenosine triphosphate passivated cadmium sulfide nanoparticles, J. Mater. Chem, 2003, 13, 1859-1861.
A.L. Rogach, L. Katsikas, A. Kornowski, Dangsheng Su, A. Eychmüller and H. Weller, Synthesis and Characterization of Thiol-Stabilized CdTe Nanocrystals, Ber. Bunsenges. Phys. Chem. 100, 1772-1778 (1996) No. 11.
B.V. Enüstün and John Turkevich, Coagulation of Colloidal Gold, Journal of the American Chemical Society, vol. 85, No. 21, Nov. 5, 1963, 3317-3328.
M.K. Chow and C. F. Zukoski, Gold Sol Formation Mechanisms: Role of Colloidal Stability, Journal of Colloid and Interface Science, 165, 97-109 (1994).
Zhan Li, Yumin Du, Biomimic synthesis of CdS nanoparticles with enhanced luminescence, Science Direct, Materials Letters 57 (2003) 2480-2484.
Richard Kho, Claudia L. Torres-Martinez and Rajesh K. Mehra, A Simple Colloidal Synthesis for Gram-Quantity Production of Water-Soluble ZnS Nanocrystal Powders, Journal of Colloid and Interface Science 277, 561-566 (2000).
Warren CW Chan, Dustin J. Maxwell, Xiaohu Gao, Robert E. Bailey, Mingyong Han and Shuming Nie, Luminescent quantum dots for multiplexed biological detection and imaging, Current Opinion in Biotechnology 2002, 13:40-46.
L.E. Brus, Electron-electron and electron-hole interactions in small semiconductor crystallites: The size of dependence of the lowest excited electronic state, J.Chem.Phys. 80(9), May 1, 1984, 4403-4409.
Darren Lawless, Sudhir Kapoor and Dan Meisel, Bifunctional Capping of CdS Nanoparticles and Bridging to TiO2, J. Phys. Chem. 1995, 99, 103259-10335.
Li Hui
Schillo Melissa Colleen
Shih Wan Y.
Shih Wei-Heng
Drexel University
Knoble & Yoshida & Dunleavy LLC
Vanoy Timothy C
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