Water-soluble mutein of FGF receptor, DNA and production thereof

Details Water-soluble mutein of FGF receptor, DNA and production thereof Water-soluble mutein of FGF receptor, DNA and production thereof

1995-06-06

1998-05-12

Spector, Lorraine M.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

4351723, 435361, 43525233, 4353201, 530350, 536 235, 935 10, 935 73, C07K 1471, C07H 2100, C12N 1512, C12N 1563

Patent

active

057503710

ABSTRACT:
Disclosed are (1) a water-soluble mutein of an animal protein having activity as a receptor for a fibroblast growth factor (FGF) protein, (2) a recombinant DNA having a nucleotide sequence coding for the above water-soluble mutein, (3) a vector containing the above recombinant DNA, (4) a transformant transformed with the above vector, and (5) a process for producing the water-soluble mutein which comprises cultivating the above transformant in a culture medium, the mutein being useful as therapeutic agents or to enhance cell proliferation activity.

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Seno et al., Biochimica et Biophysica Acta, 1089:244-246, 1991.
Dionne et al., The EMBO Journal, 9(9):2685-2692 (1990).
Hattori et al., Proc. Natl. Acad. Sci USA, 87(15):5983-5987, Aug. 1990.

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