Water soluble monoesters as solubilisers for pharmacologically a

Details Water soluble monoesters as solubilisers for pharmacologically a Water soluble monoesters as solubilisers for pharmacologically a

1994-11-07

1998-05-26

Davenport, Avis M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530317, A61K 3800, A61K 3802, C07K 500, C07K 700

Patent

active

057564507

ABSTRACT:
A combination of a pharmacologically active compound and a water soluble monoester of a saturated or unsaturated (C.sub.6-18) fatty acid and a polyol, especially a saccharide, particularly as a solid solution of the active compound in the monoester.
The solid solution is especially suitable for substantially water insoluble active compounds, particularly such polypeptides, e.g. ciclosporins and is in all desirable weight ratios miscible with water.
The invention also, in particular, provides pharmaceutical compositions comprising a cyclosporin as active ingredient together with a fatty acid saccharide monoester.

REFERENCES:
patent: 4388307 (1983-06-01), Cavanak
patent: 4798823 (1989-01-01), Witzel
patent: 4943560 (1990-07-01), Wigness et al.
Chemical Abstracts No. 107: 46298;.
Chemical Abstracts No. 95: 225610 K.
Takada et al., Chem. Abstr. vol. 107 No. 6., 1986 Abst. No. 46298j.
Anon, Chem Abstr, vol. 95, 1981, p. 375, Abst. No. 225610K.
Chemical Abstracts, vol. 75, 1981, CH: 225610K.
Tatada et al. Chemical Abstract, vol. 107(1), 1986 CH: 46298J.

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