Water-soluble mono-PEGylated tetrapyrrole derivatives for...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C540S145000

Reexamination Certificate

active

06949581

ABSTRACT:
Water-soluble mono-PEGylated tetrapyrrole derivatives are disclosed, having a formula given by formula 1, 2, or 3 in the specification. A method to produce the above water-soluble mono-PEGylated compounds is also disclosed, comprising an interaction of a tetrapyrrole with an aminopolyethylene glycol containing a functionalized terminal fragment, as well as their use as photosensitizers in photodynamic therapy.

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Bonnett, “Photodynamic Therapy in Historical Perspective”, Rev. Contemp. Pharmacother. 1999; 10:1-17.
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