Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Cosmetic – antiperspirant – dentifrice
Patent
1996-01-04
1997-10-21
Venkat, Jyothsan
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Cosmetic, antiperspirant, dentifrice
424677, 424681, 514844, 514969, A01K 748
Patent
active
056793596
DESCRIPTION:
BRIEF SUMMARY
The present invention relates to the use of water-soluble magnesium salts in formulations which are to be externally applied and to the use of water-soluble magnesium salts for the manufacture of external formulations as well as to novel external preparations containing water-soluble magnesium salts in combination with vitamin E and/or vitamin E esters.
From EP-A 0 439 640 there has been known that inflammatory diseases of the skin and allergically inflammatory reactions of the skin can be treated with externally applicable formulations containing from 0.5 to 30% by weight of water-soluble magnesium salts. It is an essential feature of these external preparations that they contain no or virtually no calcium ions, so that calcium can be displaced by magnesium, thereby to inhibit the inflammation enzymes. Such a preparation meanwhile has been marketed by Applicant under the designation of Wogederm.RTM.. It contains 25% by weight of magnesium chloride, conventional ointment bases and no added calcium salts.
It has now been determined that such preparations containing at least 0.5% by weight, and preferably 5% by weight, of water-soluble magnesium salts are further capable of lessening UV light-induced damages to the skin and thereby, more particularly, to weaken, or even fully prevent, premature aging and the generation of skin cancer by UV light. It has further been determined that the light-protective action known from DE-A-35 07 791 of vitamin E and/or vitamin E esters is significantly enhanced by the simultaneous presence of water-soluble magnesium salts, so that it offers itself to provide combination preparations which contain
Since the magnesium salts in the externally applicable formulations are to be water-soluble, it is primarily magnesium chloride that is taken into consideration. Magnesium sulfate is less suitable. Also the other water-soluble magnesium salts, including those of organic acids, must be well tolerated and, above all, must not induce any allergic reaction or other irritation of the skin.
The formulations considered for external application mainly include ointments, creams, lotions, aqueous tonics and shampoos. These in the first place are cosmetic preparations, while also preparations are contemplated that can be marketed only as drugs. This will, more specifically, depend on whether the base and auxiliary materials are allowed for the manufacture of cosmetics or solely for the formulation of drugs, and whether the preparations will be offered also for other purposes illustrated by a statement on healing and, hence, are declared as medicaments.
The preparations used according to the invention, depending on the intended use, may be produced as water-in-oil or as oil-in-water emulsions which will either fast penetrate into the skin or will at least partially remain as a greasy film on the surface of the skin for an extended period of time. The water-soluble magnesium salts from lotions, aqueous tonics and shampoos in general will fast penetrate into the skin so that they may display their light-protective action therein. The concentration of magnesium salts, and especially of magnesium chloride, may be selected to be between 0.5% and 30% by weight, depending on the kind of application. It is preferred that concentrations between 5 and 30% by weight are selected.
The contents of vitamin E and/or vitamin E esters may also be selected from within wide limits of between 0.4% and 25% by weight. It is preferred that the compositions contain from 5% to 20% by weight of vitamin E and/or vitamin E ester. Preferred are formulations from which vitamin E and/or vitamin E ester can readily penetrate into the skin, such as those according to DE-B-35 07 791 and to EP-B 0 158 090.
Thus, the new external preparations according to the invention containing the combination of water-soluble magnesium salt and vitamin E and/or vitamin E esters primarily utilize ointment bases which are suitable to facilitate the penetration into the skin of vitamin E and/or its esters. For this reason, formulations based on
Venkat Jyothsan
Wogepharm GmbH
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