Chemistry: analytical and immunological testing – Involving an insoluble carrier for immobilizing immunochemicals – Carrier is inorganic
Reexamination Certificate
2007-03-20
2007-03-20
Chin, Christopher L. (Department: 1641)
Chemistry: analytical and immunological testing
Involving an insoluble carrier for immobilizing immunochemicals
Carrier is inorganic
C420S528000, C420S555000, C420S576000, C420S577000, C257S064000, C257S040000, C257S200000, C257S613000, C257S164000, C257S242000, C428S402000, C428S403000, C430S056000, C430S060000, C435S006120, C436S525000
Reexamination Certificate
active
10228716
ABSTRACT:
The present invention provides a water-soluble luminescent quantum dot, a biomolecular conjugate thereof and a composition comprising such a quantum dot or conjugate. Additionally, the present invention provides a method of obtaining a luminescent quantum dot, a method of making a biomolecular conjugate thereof, and methods of using a biomolecular conjugate for ultrasensitive nonisotopic detection in vitro and in vivo.
REFERENCES:
patent: 3996345 (1976-12-01), Ullman et al.
patent: 4637988 (1987-01-01), Hinshaw et al.
patent: 4777128 (1988-10-01), Lippa
patent: 5248772 (1993-09-01), Siiman et al.
patent: 5319209 (1994-06-01), Miyakawa et al.
patent: 5389377 (1995-02-01), Chagnon et al.
patent: 5441746 (1995-08-01), Chagnon
patent: 5505928 (1996-04-01), Alivisatos et al.
patent: 5674698 (1997-10-01), Zarling et al.
patent: 5751018 (1998-05-01), Alivisatos et al.
patent: 5990479 (1999-11-01), Weiss et al.
patent: 6114038 (2000-09-01), Castro et al.
patent: 6251303 (2001-06-01), Bawendi et al.
patent: 6309701 (2001-10-01), Barbera-Guillem
patent: 6548171 (2003-04-01), Barbera-Guillem et al.
patent: 6680211 (2004-01-01), Barbera-Guillem et al.
patent: 0 990 903 (2000-04-01), None
patent: 2 342 651 (2000-04-01), None
patent: WO 90/15666 (1990-12-01), None
patent: WO 91/09678 (1991-07-01), None
patent: WO 93/15117 (1993-08-01), None
patent: WO 93/26019 (1993-12-01), None
patent: WO 98/04740 (1998-02-01), None
patent: WO 98/33070 (1998-07-01), None
patent: WO 00/17656 (2000-03-01), None
patent: WO 00/17665 (2000-03-01), None
Alivisatos et al., “Organization of Nanocrystal Molecules Using DNA,”Nature,382, 609-611 (1996).
Alivisatos, “Semiconductor Clusters, Nanocrystals, and Quantum Dots,”Science,271, 933-37 (1996).
Alivisatos, “Perspectives on the Physical Chemistry of Semiconductor Nanocrystals,”J. Phys. Chem.,100(31) 13226-13229 (1996).
Blanton et al., “Photoluminescence Wandering in Single CdSe Nanocrystals,”Appl. Phys. Lett.,69, 3905 (1996).
Bowden Katari et al., “X-ray Photoelectron Spectroscopy of CdSe Nanocrystals with Applications to Studies of the Nanocrystal Surfaces,”J. Phys. Chem.,98, 4109-4117 (1994).
Bruchez et al., “Semiconductor Nanocrystals as Fluorescent Biological Labels,”Science,281 (281), 2013-2016 (1998).
Bruchez et al., “Semiconductor Nanocrystals as Fluoredcent Probes for Biology,”Cytometry,Supp. 9, 26 (1998).
Brus, “Quantum Crystallites and Nonlinear Optics,”Appl. Phys.,A 53, 465-74 (1991).
Chan et al., “Quantum Dot Bioconjugates for Ultrasensitive Nonisotopic Detection,”Science,281 (281), 2016-2018 (1998).
Coffer et al., “Characterization of Quantum-Confined CdS Nanocrystallites Stabilized by Deoxyribonucleic Acid (DNA),”Nanotechnol.,3, 69-76 (1992).
Covin et al. (1994). “Light-emitting Diodes Made from Cadmium Selenide Nanocrystals and a Semiconducting Polymer.”Nature.370:354-357.
Danek et al. (1996). “Synthesis of Luminescent Thin-film CdSe/ZnSe Quantum Dot Composites Using CdSe Quantum Dots Passivated with an Overlayer of ZnSe.”Chem. Mat. 8:173-180.
Dabbousi et al. (1995). “Electroluminescence from CdSe Quantum-dot/polymer Composites.”Appl. Phys. Lett. 66(11):1316-1318.
Dabbousi et al., “CdSe)ZnS Core-Shell Quantum Dots: Synthesis and Characterization of a Size Series of Highly Luminescent Nanocrystallites,”J. Phys. Chem.,B 101: 9463-9475 (1997).
Edwards et al., “The Nucleation of Receptor-Mediated Endocytosis,”PNAS,93(5), 1786-1791 (1996).
Empedocles et al., “Photoluminescence Spectroscopy of Single CdSe Nanocrystallite Quantum Dots,”Phys. Rev. Lett.,77, 3873 (1996).
Henglein, “Small-Particle Research: Physicochemical Properties of Extremely Small Colloidal Metal Semiconductor Particles,”Chem. Rev.,89, 1861-73 (1989).
Hines et al., “Synthesis and Characterization of Strongly Luminescing ZnS-Capped CdSe Nanocrystals,”J. Phys. Chem.,100, 468-71 (1996).
Jacoby, “Quantum Dots Meet Biomolecules,”C&E News,9/28, 8 (, 819, 898, 8).
Kagan et al., “Electronic Energy Transfer in CdSe Quantum Dot Solids,”Phys. Rev. Lett.,76, 1577-1580 (1996).
Kuno et al., “Band Edge Luminescence of Surface Modified CdSe Nanocrystallites: Probing the Luminescing State,”J. Chem. Phys.,106, 9869-9882 (1997).
Lawless et al. (1995). “Bifunctional Capping of CdS Nanoparticles and Bridging to TiO2.”J. Phys. Chem. 99:10329-10335.
Lee et al., “Surface Derivatization of Nanocrystalline CdSe Semiconductors,”Mat. Res. Soc. Symp. Proc.,452, 232-328 (1997).
Liz-Marzan et al., “Synthesis of Nanosized Gold-Silica Core-Shell Particles,”Langmuir,12, 4329-4335 (1996).
Matsumoto et al. (1996). “Preparation of Nonodisperse CdS Nanocrystals by Size Selective Photocorrosion.”J. Phys. Chem. 100:13781-13785.
Mahtab et al., “Preferential-Absorption of a ‘Kinked’ DNA to a Neutral Curved Surface: Comparison to and Implications for Nonspecific DNA-Protein Interactions,”J. Am. Chem. Soc.,118, 7028-7032 (1996).
Mikulec et al., “Fluorescent Semiconductor Nanocrystallites Derivatized with Biomolecules,”Abst. Papers of Am. Chem. Soc.,216 (3), P 018 MACR (1996).
Mikulec et al.,Mat. Res. Soc. Symp.,452, 359-364 (1997).
Mitchell et al., “Programmed Assembly of DNA Functionalized Quantum Dots,”Journal of the American Chemical Society,121 (35), 8122-8123 (1999).
Moronne et al., “Nanocrystal Phosphors as Biological Probes for Fluorescence Microscopy,”Biophysical Journal,76, A450 (1999).
Murphy, “Optical Probes of DNA Bending,”Database Chemical Abstracts ′Online?,Accession No. 1996:414531 CAPLUS, XP002143843 Abstract (1996).
Murphy et al., “Quantum Dots as Inorganic DNA-Binding Proteins,”Mat. Res. Soc. Symp.,452, 597-600 (1997).
Murray et al., “Synthesis and Characterization of Nearly Monodisperse CdE (E=S, Se, Te) Semiconductor Nanocrystallites,”J. Am. Chem. Soc.,115(19): 8706-8715 (1993).
Nirmal et al., “Fluorescence Intermittency in Single Cadmium Selenide Nanocrystals,”Nature,383:802-804 (1996).
Nicolaou et al., “Radiofrequency Encoded Cominatorial Chemistry,”Ignew. Chem. Int. Ed. Engl.,34, 2289-2291 (1995).
Norris et al. (1996). “Measurement and Assignment of the Size-dependent Optical Spectrum in CdSe Quantum Dots.”Phys. Rev. B. 53(24):16338-16346.
Norris et al. (1996). “Size Dependence of Exciton Fine Structure in CdSe Quantum Dots.”Phys. Rev. B. 53(24):16347-16354.
Peng et al., “Epitaxial Growth of Highly Luminescent CdSe/CdS Core/Shell Nanocrystals with Photostability and Electronic Accessibility,”J. Am. Chem. Soc.,119, 7019-1029 (1997).
Smythe et al., “The Mechanism of Receptor-Mediated Endocytosis,”Eur. J. Biochem.,202, 689 (1991).
Shrock et al., “Multicolor Spectral Karyotyping of Human Chromosomes,”Science,273, 494-497 (1996).
Weller, “Colloidal Semiconductor Q-Particle: Chemistry in the Transition Region Between Solid State and Molecules,”Angew. Chem. Int. Ed. Engl.,32, 41-53 (1993).
Whitesell et al., “Directionally Aligned Helical Peptides on Surfaces,”Science,261, 73-76 (1993).
Wilson et al., “Quantum Confinement in Size-Selected, Surface-Oxidized Silicon Nanocrystals,”Science,262, 1242-46 (1993).
Zhang et al., “Novel Flow Cytometry Compensation Standards: Internally Stained Fluorescent Microspheres with Matched Emission Spectra and Long-Term Stability,”Cytometry,33, 244-248 (1998).
Syvänen,Medical Biology,64, 313-324 (1986).
Chan Warren C. W.
Emory Stephen
Nie Shuming
Chin Christopher L.
Indiana University Research and Technology Corporation
Leydig Voit & Mayer Ltd
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